FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018199835> ?p ?o ?g. }

• W2018199835 endingPage "1158" @default.
• W2018199835 startingPage "1148" @default.
• W2018199835 abstract "We have synthesized a series of cationic amino acid-based lipids having a spacer between the cationic head group and hydrophobic moieties and examined the influence of the spacer on a liposome gene delivery system. As a comparable spacer, a hydrophobic spacer with a hydrocarbon chain composed of 0, 3, 5, 7, or 11 carbons, and a hydrophilic spacer with an oxyethylene chain (10 carbon and 3 oxygen molecules) were investigated. Plasmid DNA (pDNA)-encapsulating liposomes were prepared by mixing an ethanol solution of the lipids with an aqueous solution of pDNA. The zeta potentials and cellular uptake efficiency of the cationic liposomes containing each synthetic lipid were almost equivalent. However, the cationic lipids with the hydrophobic spacer were subject to fuse with biomembrane-mimicking liposomes. 1,5-Dihexadecyl-N-lysyl-N-heptyl-l-glutamate, having a seven carbon atom spacer, exhibited the highest fusogenic potential among the synthetic lipids. Increased fusion potential correlated with enhanced gene expression efficiency. By contrast, an oxyethylene chain spacer showed low gene expression efficiency. We conclude that a hydrophobic spacer between the cationic head group and hydrophobic moieties is a key component for improving pDNA delivery." @default.
• W2018199835 created "2016-06-24" @default.
• W2018199835 creator A5037131620 @default.
• W2018199835 creator A5040277267 @default.
• W2018199835 creator A5070435252 @default.
• W2018199835 creator A5083303483 @default.
• W2018199835 date "2009-05-01" @default.
• W2018199835 modified "2023-10-12" @default.
• W2018199835 title "Plasmid DNA-encapsulating liposomes: Effect of a spacer between the cationic head group and hydrophobic moieties of the lipids on gene expression efficiency" @default.
• W2018199835 cites W1546818242 @default.
• W2018199835 cites W1965680025 @default.
• W2018199835 cites W1966334833 @default.
• W2018199835 cites W1967476833 @default.
• W2018199835 cites W1970885064 @default.
• W2018199835 cites W1972845382 @default.
• W2018199835 cites W1973884421 @default.
• W2018199835 cites W1987009228 @default.
• W2018199835 cites W1988537267 @default.
• W2018199835 cites W1991807751 @default.
• W2018199835 cites W1993776299 @default.
• W2018199835 cites W1994783048 @default.
• W2018199835 cites W1996015474 @default.
• W2018199835 cites W1996449288 @default.
• W2018199835 cites W1996491430 @default.
• W2018199835 cites W1996721791 @default.
• W2018199835 cites W1997103748 @default.
• W2018199835 cites W2000130544 @default.
• W2018199835 cites W2009869719 @default.
• W2018199835 cites W2011463648 @default.
• W2018199835 cites W2018075799 @default.
• W2018199835 cites W2023254910 @default.
• W2018199835 cites W2024256121 @default.
• W2018199835 cites W2024361708 @default.
• W2018199835 cites W2034048441 @default.
• W2018199835 cites W2041121504 @default.
• W2018199835 cites W2042487849 @default.
• W2018199835 cites W2044941596 @default.
• W2018199835 cites W2044945512 @default.
• W2018199835 cites W2066606615 @default.
• W2018199835 cites W2068588309 @default.
• W2018199835 cites W2070470578 @default.
• W2018199835 cites W2074217327 @default.
• W2018199835 cites W2078532145 @default.
• W2018199835 cites W2080648192 @default.
• W2018199835 cites W2081884104 @default.
• W2018199835 cites W2084652077 @default.
• W2018199835 cites W2090742333 @default.
• W2018199835 cites W2091955078 @default.
• W2018199835 cites W2103628727 @default.
• W2018199835 cites W2107638822 @default.
• W2018199835 cites W2108192438 @default.
• W2018199835 cites W2111190377 @default.
• W2018199835 cites W2133732437 @default.
• W2018199835 cites W2133782648 @default.
• W2018199835 cites W2136240349 @default.
• W2018199835 cites W2143875501 @default.
• W2018199835 cites W2145998984 @default.
• W2018199835 cites W2148665822 @default.
• W2018199835 cites W2167551641 @default.
• W2018199835 doi "https://doi.org/10.1016/j.bbamem.2009.02.014" @default.
• W2018199835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19249283" @default.
• W2018199835 hasPublicationYear "2009" @default.
• W2018199835 type Work @default.
• W2018199835 sameAs 2018199835 @default.
• W2018199835 citedByCount "48" @default.
• W2018199835 countsByYear W20181998352012 @default.
• W2018199835 countsByYear W20181998352013 @default.
• W2018199835 countsByYear W20181998352014 @default.
• W2018199835 countsByYear W20181998352015 @default.
• W2018199835 countsByYear W20181998352016 @default.
• W2018199835 countsByYear W20181998352017 @default.
• W2018199835 countsByYear W20181998352018 @default.
• W2018199835 countsByYear W20181998352019 @default.
• W2018199835 countsByYear W20181998352020 @default.
• W2018199835 countsByYear W20181998352021 @default.
• W2018199835 countsByYear W20181998352023 @default.
• W2018199835 crossrefType "journal-article" @default.
• W2018199835 hasAuthorship W2018199835A5037131620 @default.
• W2018199835 hasAuthorship W2018199835A5040277267 @default.
• W2018199835 hasAuthorship W2018199835A5070435252 @default.
• W2018199835 hasAuthorship W2018199835A5083303483 @default.
• W2018199835 hasConcept C104317684 @default.
• W2018199835 hasConcept C12554922 @default.
• W2018199835 hasConcept C135983454 @default.
• W2018199835 hasConcept C155672457 @default.
• W2018199835 hasConcept C155887181 @default.
• W2018199835 hasConcept C171250308 @default.
• W2018199835 hasConcept C183882617 @default.
• W2018199835 hasConcept C185154212 @default.
• W2018199835 hasConcept C185592680 @default.
• W2018199835 hasConcept C188027245 @default.
• W2018199835 hasConcept C192562407 @default.
• W2018199835 hasConcept C54009773 @default.
• W2018199835 hasConcept C55493867 @default.
• W2018199835 hasConcept C71240020 @default.
• W2018199835 hasConcept C86181022 @default.
• W2018199835 hasConcept C86803240 @default.
• W2018199835 hasConcept C90260826 @default.

• next