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- W2018201249 abstract "Cationic local anesthetics inhibit competitively the stereospecific binding of naltrexone and etorphine on the mouse brain opiate receptor. In contrast, the inhibition produced by benzocaine, a non-cationic local anesthetic, is non-competitive. It is suggested that the cationic group of local anesthetics interacts with a specific anionic binding site on the opiate receptor and that there are certain structural similarities between the receptors for both types of drugs. It is evident from these studies that several drugs can unspecifically modify the pharmacologic effects of opiates and that they could be useful tools to further characterize the opiate receptor." @default.
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- W2018201249 title "Competitive inhibition of stereospecific opiate binding by local anesthetics in mouse brain" @default.
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- W2018201249 doi "https://doi.org/10.1016/0024-3205(75)90279-9" @default.
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