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- W2018202338 abstract "Chlorofluorocarbon (CFC)–containing inhalers are gradually being phased out and replaced with hydrofluoroalkane (HFA)–based alternatives. The reformulation provided the opportunity to improve the inhalation technology and physical characteristics of corticosteroid formulations. QVAR contains HFA-beclomethasone dipropionate (HFA-BDP) with the steroid in solution rather than suspension, which, in combination with improved inhaler technology, produces an extrafine aerosol with a mass median aerodynamic diameter of 1.1 μm (smaller than the 3.5-4.0 μm found with CFC-BDP). It was predicted and demonstrated that the smaller particle size of QVAR would be deposited in the lung to a greater extent than that found with CFC-BDP, particularly in the small airway, a major site of inflammation. Increased lung deposition of QVAR permits a reduction in dosage relative to CFC-BDP. Clinical evidence confirms that adult and elderly patients required approximately half the dose of QVAR to achieve the same degree of asthma control as with CFC-BDP. In long-term assessments, patients taking CFC-BDP could be switched to QVAR at half the daily dose without exacerbation of their asthma symptoms. QVAR was associated with a low overall incidence of side effects and, at the maximum recommended dose of 640 μg/d, caused no more adrenal suppression than 672 μg/d CFC-BDP. (J Allergy Clin Immunol 2000;106:1209-26.)" @default.
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- W2018202338 date "2000-12-01" @default.
- W2018202338 modified "2023-09-27" @default.
- W2018202338 title "Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol), in asthma" @default.
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- W2018202338 doi "https://doi.org/10.1067/mai.2000.111582" @default.
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