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• W2018202893 abstract "When donors are treated with G-CSF to collect stem cells for allogeneic transplantation, the combination of a pre-apheresis leukocyte count of ≥25 × 109/L and a pre-apheresis platelet count of ≥100 × 109/L is associated with excellent mobilization as measured by an absolute peripheral blood CD34+ cell count (PBCD34) of 20/μL, and can be used to guide harvest timing (Tomblyn et al Bone Marrow Transplantation advance online publication 01 August 2005; doi: 10.1038/sj.bmt.1705117). We wanted to see if this observation could be extended to patients receiving 10–16 μg/kg G-CSF daily as the sole mobilizing agent for autologous stem cell collection. Data from 161 leukapheresis procedures (65 day 1 collections, 47 day 2 collections, and 49 collections done beyond day 2) were analyzed to determine correlation between pre-apheresis leukocytes, platelets, and PBCD34. Overall, when leukocytes ≥25 and platelets ≥100, PBCD34 was 2.9–515.5 (median 31.8); significantly (P < .0001) higher than PBCD34 of 0.6–226.0 (median 6.0) when leukocytes were <25 and/or platelets were <100. Among day 1 collections, with leukocytes ≥25 and platelets ≥100, PBCD34 was 20 and 10 in 63% and 78% of the time compared to 16% and 36% of the time if leukocytes were <25 and/or platelets were <100 (P = .0001 and P = .001, respectively). Similarly, PBCD34 levels of 20 and 10 were obtained 63% and 87% of the time with day 2 collections when leukocytes were ≥25 and platelets ≥100, compared with 19% and 35% of the time when leukocytes were <25 and/or platelets were <100 (P = .003 and 0.001, respectively). Beyond day 2, when leukocytes ≥25 and platelets ≥100, PBCD34 was 20 50% of the time compared with 7% when leukocytes were <25 and/or platelets were <100 (P = .047). Our data suggest that in patients with hematologic malignancies receiving G-CSF for mobilization of autologous stem cells, the combination of a leukocyte count of ≥25 and a platelet count of μ100 is associated with excellent mobilization of stem cells in the majority of patients on the first and second harvest days but not beyond. Conversely, lower leukocyte and/or platelet counts predict for poor mobilization beyond the second day, but not on the first two days. Thus, on the first and second days of stem cell collection in patients mobilized with G-CSF, apheresis can be initiated based on favorable hematologic parameters without necessarily awaiting PBCD34 levels. However, beyond the second day, PBCD34 levels should guide apheresis." @default.
• W2018202893 created "2016-06-24" @default.
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• W2018202893 date "2006-02-01" @default.
• W2018202893 modified "2023-09-26" @default.
• W2018202893 title "Leukocyte and platelet counts can be used to guide collection of autologous stem cells after G-CSF mobilization on the first two days of leukapheresis but not beyond" @default.
• W2018202893 doi "https://doi.org/10.1016/j.bbmt.2005.11.285" @default.
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