FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018207852> ?p ?o ?g. }

• W2018207852 endingPage "699" @default.
• W2018207852 startingPage "691" @default.
• W2018207852 abstract "Elevation of lung capillary pressure causes exocytosis of the leukocyte adhesion receptor P-selectin in endothelial cells (ECs), indicating that lung ECs generate a proinflammatory response to pressure-induced stress. To define underlying mechanisms, we followed the EC signaling sequence leading to P-selectin exocytosis through application of real-time, in situ fluorescence microscopy in lung capillaries. Pressure elevation increased the amplitude of cytosolic Ca2+ oscillations that triggered increases in the amplitude of mitochondrial Ca2+ oscillations and in reactive oxygen species (ROS) production. Responses to blockers of the Ca2+ oscillations and of mitochondrial electron transport indicated that the ROS production was Ca2+ dependent and of mitochondrial origin. A new proinflammatory mechanism was revealed in that pressure-induced exocytosis of P-selectin was inhibited by both antioxidants and mitochondrial inhibitors, indicating that the exocytosis was driven by mitochondrial ROS. In this signaling pathway mitochondria coupled pressure-induced Ca2+ oscillations to the production of ROS that in turn acted as diffusible messengers to activate P-selectin exocytosis. These findings implicate mitochondrial mechanisms in the lung’s proinflammatory response to pressure elevation and identify mitochondrial ROS as critical to P-selectin exocytosis in lung capillary ECs." @default.
• W2018207852 created "2016-06-24" @default.
• W2018207852 creator A5041142136 @default.
• W2018207852 creator A5053962419 @default.
• W2018207852 creator A5071656590 @default.
• W2018207852 creator A5076054649 @default.
• W2018207852 creator A5082030400 @default.
• W2018207852 date "2003-03-01" @default.
• W2018207852 modified "2023-10-11" @default.
• W2018207852 title "Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries" @default.
• W2018207852 cites W1495376651 @default.
• W2018207852 cites W1547863599 @default.
• W2018207852 cites W1562122315 @default.
• W2018207852 cites W1638297412 @default.
• W2018207852 cites W1649573525 @default.
• W2018207852 cites W1667711738 @default.
• W2018207852 cites W1669180776 @default.
• W2018207852 cites W1751026903 @default.
• W2018207852 cites W1879535988 @default.
• W2018207852 cites W1909841186 @default.
• W2018207852 cites W1964014243 @default.
• W2018207852 cites W1965270044 @default.
• W2018207852 cites W1967782318 @default.
• W2018207852 cites W1968540123 @default.
• W2018207852 cites W1972396107 @default.
• W2018207852 cites W1974913500 @default.
• W2018207852 cites W1976348423 @default.
• W2018207852 cites W1983820893 @default.
• W2018207852 cites W1985977889 @default.
• W2018207852 cites W1997468404 @default.
• W2018207852 cites W2003060168 @default.
• W2018207852 cites W2009041168 @default.
• W2018207852 cites W2010055809 @default.
• W2018207852 cites W2010908003 @default.
• W2018207852 cites W2014084783 @default.
• W2018207852 cites W2020138346 @default.
• W2018207852 cites W2028702612 @default.
• W2018207852 cites W2034252573 @default.
• W2018207852 cites W2034942794 @default.
• W2018207852 cites W2042023540 @default.
• W2018207852 cites W2045504893 @default.
• W2018207852 cites W2047953835 @default.
• W2018207852 cites W2051340998 @default.
• W2018207852 cites W2055478604 @default.
• W2018207852 cites W2063535351 @default.
• W2018207852 cites W2063646489 @default.
• W2018207852 cites W2065520371 @default.
• W2018207852 cites W2069568986 @default.
• W2018207852 cites W2073706613 @default.
• W2018207852 cites W2079793296 @default.
• W2018207852 cites W2079941180 @default.
• W2018207852 cites W2088835245 @default.
• W2018207852 cites W2091154394 @default.
• W2018207852 cites W2092109656 @default.
• W2018207852 cites W2096204372 @default.
• W2018207852 cites W2106971003 @default.
• W2018207852 cites W2111189439 @default.
• W2018207852 cites W2117127822 @default.
• W2018207852 cites W2119825205 @default.
• W2018207852 cites W2123355036 @default.
• W2018207852 cites W2139052757 @default.
• W2018207852 cites W2139173753 @default.
• W2018207852 cites W2154529942 @default.
• W2018207852 cites W2196938970 @default.
• W2018207852 cites W2337405092 @default.
• W2018207852 cites W251053485 @default.
• W2018207852 doi "https://doi.org/10.1172/jci17271" @default.
• W2018207852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151903" @default.
• W2018207852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12618523" @default.
• W2018207852 hasPublicationYear "2003" @default.
• W2018207852 type Work @default.
• W2018207852 sameAs 2018207852 @default.
• W2018207852 citedByCount "117" @default.
• W2018207852 countsByYear W20182078522012 @default.
• W2018207852 countsByYear W20182078522013 @default.
• W2018207852 countsByYear W20182078522014 @default.
• W2018207852 countsByYear W20182078522015 @default.
• W2018207852 countsByYear W20182078522016 @default.
• W2018207852 countsByYear W20182078522017 @default.
• W2018207852 countsByYear W20182078522018 @default.
• W2018207852 countsByYear W20182078522019 @default.
• W2018207852 countsByYear W20182078522020 @default.
• W2018207852 countsByYear W20182078522021 @default.
• W2018207852 countsByYear W20182078522022 @default.
• W2018207852 countsByYear W20182078522023 @default.
• W2018207852 crossrefType "journal-article" @default.
• W2018207852 hasAuthorship W2018207852A5041142136 @default.
• W2018207852 hasAuthorship W2018207852A5053962419 @default.
• W2018207852 hasAuthorship W2018207852A5071656590 @default.
• W2018207852 hasAuthorship W2018207852A5076054649 @default.
• W2018207852 hasAuthorship W2018207852A5082030400 @default.
• W2018207852 hasBestOaLocation W20182078521 @default.
• W2018207852 hasConcept C164027704 @default.
• W2018207852 hasConcept C175969161 @default.
• W2018207852 hasConcept C181199279 @default.
• W2018207852 hasConcept C185592680 @default.
• W2018207852 hasConcept C203014093 @default.
• W2018207852 hasConcept C2776151105 @default.

• next