Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018207937> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2018207937 endingPage "172" @default.
- W2018207937 startingPage "165" @default.
- W2018207937 abstract "The generation of thrombin and its various activities have to be tightly controlled in the circulation as well as at extracellular sites to prevent pathological situations. Both vessel wall-associated thrombomodulin and circulating serine protease inhibitors meet the requirements for regulation of thrombin function. The final products of thrombin inhibition are ternary complexes together with the adhesion protein vitronectin. Due to a conformational switch in the vitronectin molecule, ternary complexes are endowed with heparin-binding properties and become specifically bound to cell surface sites on endothelial and other cells. This interaction appears to be responsible for the clearance and translocation of ternary complexes in the vasculature and at other sites. In addition, ternary complexes may provoke other cellular activities by binding to nonintegrin cell surface receptors. Along the vasculature, extracellular-associated vitronectin serves as a binding and stabilizing cofactor for plasminogen activator inhibitor 1, which thereby becomes a slow-reacting thrombin inhibitor. It is believed that clot-associated vitronectin-PAI-1 complex not only stabilizes initial thrombus formation, but is also responsible for thrombin neutralization and the necessary switch towards fibrinolysis. Vitronectin thereby becomes an integral cofactor for regulation and control of thrombin multifunctional activities." @default.
- W2018207937 created "2016-06-24" @default.
- W2018207937 creator A5000317180 @default.
- W2018207937 creator A5018921345 @default.
- W2018207937 creator A5048716653 @default.
- W2018207937 creator A5075056860 @default.
- W2018207937 date "1996-04-01" @default.
- W2018207937 modified "2023-09-25" @default.
- W2018207937 title "Thrombin Regulation by Physiological Inhibitors: The Role of Vitronectin" @default.
- W2018207937 doi "https://doi.org/10.1055/s-2007-999005" @default.
- W2018207937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8807714" @default.
- W2018207937 hasPublicationYear "1996" @default.
- W2018207937 type Work @default.
- W2018207937 sameAs 2018207937 @default.
- W2018207937 citedByCount "25" @default.
- W2018207937 crossrefType "journal-article" @default.
- W2018207937 hasAuthorship W2018207937A5000317180 @default.
- W2018207937 hasAuthorship W2018207937A5018921345 @default.
- W2018207937 hasAuthorship W2018207937A5048716653 @default.
- W2018207937 hasAuthorship W2018207937A5075056860 @default.
- W2018207937 hasConcept C123012128 @default.
- W2018207937 hasConcept C12554922 @default.
- W2018207937 hasConcept C126322002 @default.
- W2018207937 hasConcept C164144092 @default.
- W2018207937 hasConcept C170493617 @default.
- W2018207937 hasConcept C181199279 @default.
- W2018207937 hasConcept C185592680 @default.
- W2018207937 hasConcept C195687474 @default.
- W2018207937 hasConcept C201267052 @default.
- W2018207937 hasConcept C202751555 @default.
- W2018207937 hasConcept C203014093 @default.
- W2018207937 hasConcept C2776714187 @default.
- W2018207937 hasConcept C2776825266 @default.
- W2018207937 hasConcept C2777292125 @default.
- W2018207937 hasConcept C2777807008 @default.
- W2018207937 hasConcept C2778162025 @default.
- W2018207937 hasConcept C55493867 @default.
- W2018207937 hasConcept C71924100 @default.
- W2018207937 hasConcept C86756495 @default.
- W2018207937 hasConcept C86803240 @default.
- W2018207937 hasConcept C89560881 @default.
- W2018207937 hasConcept C95444343 @default.
- W2018207937 hasConceptScore W2018207937C123012128 @default.
- W2018207937 hasConceptScore W2018207937C12554922 @default.
- W2018207937 hasConceptScore W2018207937C126322002 @default.
- W2018207937 hasConceptScore W2018207937C164144092 @default.
- W2018207937 hasConceptScore W2018207937C170493617 @default.
- W2018207937 hasConceptScore W2018207937C181199279 @default.
- W2018207937 hasConceptScore W2018207937C185592680 @default.
- W2018207937 hasConceptScore W2018207937C195687474 @default.
- W2018207937 hasConceptScore W2018207937C201267052 @default.
- W2018207937 hasConceptScore W2018207937C202751555 @default.
- W2018207937 hasConceptScore W2018207937C203014093 @default.
- W2018207937 hasConceptScore W2018207937C2776714187 @default.
- W2018207937 hasConceptScore W2018207937C2776825266 @default.
- W2018207937 hasConceptScore W2018207937C2777292125 @default.
- W2018207937 hasConceptScore W2018207937C2777807008 @default.
- W2018207937 hasConceptScore W2018207937C2778162025 @default.
- W2018207937 hasConceptScore W2018207937C55493867 @default.
- W2018207937 hasConceptScore W2018207937C71924100 @default.
- W2018207937 hasConceptScore W2018207937C86756495 @default.
- W2018207937 hasConceptScore W2018207937C86803240 @default.
- W2018207937 hasConceptScore W2018207937C89560881 @default.
- W2018207937 hasConceptScore W2018207937C95444343 @default.
- W2018207937 hasIssue "02" @default.
- W2018207937 hasLocation W20182079371 @default.
- W2018207937 hasLocation W20182079372 @default.
- W2018207937 hasOpenAccess W2018207937 @default.
- W2018207937 hasPrimaryLocation W20182079371 @default.
- W2018207937 hasRelatedWork W1556646709 @default.
- W2018207937 hasRelatedWork W1974208990 @default.
- W2018207937 hasRelatedWork W1992696073 @default.
- W2018207937 hasRelatedWork W2001243202 @default.
- W2018207937 hasRelatedWork W2013764692 @default.
- W2018207937 hasRelatedWork W2018207937 @default.
- W2018207937 hasRelatedWork W2028604893 @default.
- W2018207937 hasRelatedWork W2191453871 @default.
- W2018207937 hasRelatedWork W23209346 @default.
- W2018207937 hasRelatedWork W2332285614 @default.
- W2018207937 hasVolume "22" @default.
- W2018207937 isParatext "false" @default.
- W2018207937 isRetracted "false" @default.
- W2018207937 magId "2018207937" @default.
- W2018207937 workType "article" @default.