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- W2018215900 abstract "In Alzheimer's disease (AD) β-amyloid peptide accumulates in the brain in different forms including fibrils. Amyloid fibrils could be recognized as foreign by the mature immune system since they are not present during its development. Thus, using mouse antisera raised against the fibrillar form of Aβ42, we have screened two phage peptide libraries for the presence of foreign conformational mimotopes of Aβ. Antisera from wild type animals recognized predominately peptides with the EFRH motif from Aβ42 sequence, whereas amyloid precursor protein (APP) transgenic mice recognized mainly phage clones that mimic epitopes (mimotopes) within the fibrillar Aβ42 but lack sequence homology with this peptide." @default.
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- W2018215900 date "2004-11-01" @default.
- W2018215900 modified "2023-10-17" @default.
- W2018215900 title "Mimotopes of conformational epitopes in fibrillar β-amyloid" @default.
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- W2018215900 doi "https://doi.org/10.1016/j.jneuroim.2004.06.004" @default.
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