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- W2018216360 abstract "Two different classes of therapy-related acute myeloid leukemia (t-AML) seem to emerge. One class follows therapy with alkylating agents, increases in frequency with age, often presents with myelodysplasia (MDS), responds poorly to chemotherapy, and shows monosomy 7(-7), monosomy 5(-5), or loss of various parts of the long arms of these chromosomes (5q- and 7q-). The other class is related to therapy with cytostatic drugs targeting at DNA-topoisomerase II, often presents with overt leukemia, responds more favorably to chemotherapy, and shows balanced chromosome aberrations, primarily translocations involving chromosome bands 11q23 and 21q22. These two classes of t-AML may have their counterparts in de-novo acute myeloid leukemia (de-novo AML)." @default.
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- W2018216360 date "1991-08-01" @default.
- W2018216360 modified "2023-10-16" @default.
- W2018216360 title "Two different classes of therapy-related and de-novo acute myeloid leukemia?" @default.
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- W2018216360 doi "https://doi.org/10.1016/0165-4608(91)90246-q" @default.
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