FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018218096> ?p ?o ?g. }

• W2018218096 endingPage "407" @default.
• W2018218096 startingPage "397" @default.
• W2018218096 abstract "Wistar Furth (WF) rats have an abnormal thrombopoietic phenotype with morphologically aberrant megakaryocytes, larger than normal mean platelet volume, and platelet alpha-granule protein deficiency. Here, ultrastructural comparisons of WF rat megakaryocytes to those of rats (Wistar) with normal platelet formation during stimulated megakaryocytopoiesis following 5-fluorouracil administration, have revealed a previously unrecognized membrane structure in normal rat megakaryocytes, and two additional abnormalities in WF megakaryocytes. The novel structures were zones of electron density on the cytoplasmic face of apposed plasma membranes of adjoining normal megakaryocytes. These modified focal adhesion-type contacts were distributed at intervals between adjacent megakaryocytes, and were spaced by deposits of extracellular material. These structures also were present between apposed plasma membranes of Wistar rat megakaryocytes in unperturbed marrows, but were absent between megakaryocytes of WF rats. The second WF rat megakaryocyte abnormality is the absence of cytoplasmic dense compartments, another specialized membranous structure that is continuous with the megakaryocyte demarcation membrane system. Both the intercellular plaques and dense compartments of Wistar rat megakaryocytes were found to be rich in cytoskeletal proteins including actin, α-actinin, talin, and vinculin as indicated by ultrastructural immunogold labeling. We hypothesize that an abnormality in cytoskeletal protein function may be responsible for the lack of these structures in the WF rat." @default.
• W2018218096 created "2016-06-24" @default.
• W2018218096 creator A5003053323 @default.
• W2018218096 creator A5087637417 @default.
• W2018218096 creator A5090599951 @default.
• W2018218096 date "1998-01-01" @default.
• W2018218096 modified "2023-09-23" @default.
• W2018218096 title "Wistar Furth Rat Megakaryocytes Lack Dense Compartments and Intercellular Plaques, Membranous Structures Rich in Cytoskeletal Proteins" @default.
• W2018218096 cites W100209535 @default.
• W2018218096 cites W1492619899 @default.
• W2018218096 cites W1558659284 @default.
• W2018218096 cites W173776831 @default.
• W2018218096 cites W1964610374 @default.
• W2018218096 cites W1968426581 @default.
• W2018218096 cites W1978509761 @default.
• W2018218096 cites W1991201761 @default.
• W2018218096 cites W1997510272 @default.
• W2018218096 cites W2013640872 @default.
• W2018218096 cites W2018778009 @default.
• W2018218096 cites W2040503096 @default.
• W2018218096 cites W2041534105 @default.
• W2018218096 cites W2058429572 @default.
• W2018218096 cites W2075518481 @default.
• W2018218096 cites W2080030445 @default.
• W2018218096 cites W2156024234 @default.
• W2018218096 cites W2162586147 @default.
• W2018218096 cites W2169605972 @default.
• W2018218096 cites W2398260339 @default.
• W2018218096 cites W2473593613 @default.
• W2018218096 cites W38355952 @default.
• W2018218096 cites W4242838352 @default.
• W2018218096 doi "https://doi.org/10.3109/15419069809010784" @default.
• W2018218096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9789686" @default.
• W2018218096 hasPublicationYear "1998" @default.
• W2018218096 type Work @default.
• W2018218096 sameAs 2018218096 @default.
• W2018218096 citedByCount "2" @default.
• W2018218096 countsByYear W20182180962013 @default.
• W2018218096 crossrefType "journal-article" @default.
• W2018218096 hasAuthorship W2018218096A5003053323 @default.
• W2018218096 hasAuthorship W2018218096A5087637417 @default.
• W2018218096 hasAuthorship W2018218096A5090599951 @default.
• W2018218096 hasConcept C105702510 @default.
• W2018218096 hasConcept C109159458 @default.
• W2018218096 hasConcept C142669718 @default.
• W2018218096 hasConcept C142724271 @default.
• W2018218096 hasConcept C1491633281 @default.
• W2018218096 hasConcept C185592680 @default.
• W2018218096 hasConcept C190062978 @default.
• W2018218096 hasConcept C203014093 @default.
• W2018218096 hasConcept C2777918643 @default.
• W2018218096 hasConcept C2777979848 @default.
• W2018218096 hasConcept C2779705218 @default.
• W2018218096 hasConcept C28328180 @default.
• W2018218096 hasConcept C30030713 @default.
• W2018218096 hasConcept C55493867 @default.
• W2018218096 hasConcept C71924100 @default.
• W2018218096 hasConcept C79879829 @default.
• W2018218096 hasConcept C86803240 @default.
• W2018218096 hasConcept C87555872 @default.
• W2018218096 hasConcept C89560881 @default.
• W2018218096 hasConcept C95444343 @default.
• W2018218096 hasConceptScore W2018218096C105702510 @default.
• W2018218096 hasConceptScore W2018218096C109159458 @default.
• W2018218096 hasConceptScore W2018218096C142669718 @default.
• W2018218096 hasConceptScore W2018218096C142724271 @default.
• W2018218096 hasConceptScore W2018218096C1491633281 @default.
• W2018218096 hasConceptScore W2018218096C185592680 @default.
• W2018218096 hasConceptScore W2018218096C190062978 @default.
• W2018218096 hasConceptScore W2018218096C203014093 @default.
• W2018218096 hasConceptScore W2018218096C2777918643 @default.
• W2018218096 hasConceptScore W2018218096C2777979848 @default.
• W2018218096 hasConceptScore W2018218096C2779705218 @default.
• W2018218096 hasConceptScore W2018218096C28328180 @default.
• W2018218096 hasConceptScore W2018218096C30030713 @default.
• W2018218096 hasConceptScore W2018218096C55493867 @default.
• W2018218096 hasConceptScore W2018218096C71924100 @default.
• W2018218096 hasConceptScore W2018218096C79879829 @default.
• W2018218096 hasConceptScore W2018218096C86803240 @default.
• W2018218096 hasConceptScore W2018218096C87555872 @default.
• W2018218096 hasConceptScore W2018218096C89560881 @default.
• W2018218096 hasConceptScore W2018218096C95444343 @default.
• W2018218096 hasIssue "5" @default.
• W2018218096 hasLocation W20182180961 @default.
• W2018218096 hasLocation W20182180962 @default.
• W2018218096 hasOpenAccess W2018218096 @default.
• W2018218096 hasPrimaryLocation W20182180961 @default.
• W2018218096 hasRelatedWork W104583716 @default.
• W2018218096 hasRelatedWork W1996183705 @default.
• W2018218096 hasRelatedWork W2018218096 @default.
• W2018218096 hasRelatedWork W2072903422 @default.
• W2018218096 hasRelatedWork W2103632011 @default.
• W2018218096 hasRelatedWork W2123979929 @default.
• W2018218096 hasRelatedWork W2329815161 @default.
• W2018218096 hasRelatedWork W2586955483 @default.
• W2018218096 hasRelatedWork W2593811684 @default.
• W2018218096 hasRelatedWork W38355952 @default.
• W2018218096 hasVolume "5" @default.

• next