Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018222564> ?p ?o ?g. }
- W2018222564 endingPage "3452" @default.
- W2018222564 startingPage "3442" @default.
- W2018222564 abstract "YY1 is a DNA-binding transcription factor found in both vertebrates and invertebrates. Database searches identified 62 YY1 related sequences from all the available genome sequences ranging from flying insects to human. These sequences are characterized by high levels of sequence conservation, ranging from 66% to 100% similarity, in the zinc finger DNA-binding domain of the predicted proteins. Phylogenetic analyses uncovered duplication events of YY1 in several different lineages, including flies, fish and mammals. Retroposition is responsible for generating one duplicate in flies, PHOL from PHO, and two duplicates in placental mammals, YY2 and Reduced Expression 1 (REX1) from YY1. DNA-binding motif studies have demonstrated that YY2 still binds to the same consensus sequence as YY1 but with much lower affinity. In contrast, REX1 binds to DNA motifs divergent from YY1, but the binding motifs of REX1 and YY1 share some similarity at their core regions (5'-CCAT-3'). This suggests that the two duplicates, YY2 and REX1, although generated through similar retroposition events have undergone different selection schemes to adapt to new roles in placental mammals. Overall, the conservation of YY2 and REX1 in all placental mammals predicts that each duplicate has co-evolved with some unique features of eutherian mammals." @default.
- W2018222564 created "2016-06-24" @default.
- W2018222564 creator A5024951732 @default.
- W2018222564 creator A5044936635 @default.
- W2018222564 creator A5066322160 @default.
- W2018222564 date "2007-04-22" @default.
- W2018222564 modified "2023-10-10" @default.
- W2018222564 title "Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1" @default.
- W2018222564 cites W1673514954 @default.
- W2018222564 cites W1750475935 @default.
- W2018222564 cites W1796631315 @default.
- W2018222564 cites W1907806866 @default.
- W2018222564 cites W1965581435 @default.
- W2018222564 cites W1966156883 @default.
- W2018222564 cites W1981327848 @default.
- W2018222564 cites W1986905781 @default.
- W2018222564 cites W1995514235 @default.
- W2018222564 cites W1995926348 @default.
- W2018222564 cites W1997663843 @default.
- W2018222564 cites W1998580741 @default.
- W2018222564 cites W2001043267 @default.
- W2018222564 cites W2004181770 @default.
- W2018222564 cites W2015485202 @default.
- W2018222564 cites W2018486257 @default.
- W2018222564 cites W2025450279 @default.
- W2018222564 cites W2026290399 @default.
- W2018222564 cites W2035357407 @default.
- W2018222564 cites W2044547523 @default.
- W2018222564 cites W2070940247 @default.
- W2018222564 cites W2080519471 @default.
- W2018222564 cites W2082496903 @default.
- W2018222564 cites W2086150551 @default.
- W2018222564 cites W2087203311 @default.
- W2018222564 cites W2097706568 @default.
- W2018222564 cites W2103087497 @default.
- W2018222564 cites W2104744253 @default.
- W2018222564 cites W2106249020 @default.
- W2018222564 cites W2106882534 @default.
- W2018222564 cites W2115011276 @default.
- W2018222564 cites W2122441400 @default.
- W2018222564 cites W2128624858 @default.
- W2018222564 cites W2129665088 @default.
- W2018222564 cites W2140681432 @default.
- W2018222564 cites W2146396346 @default.
- W2018222564 cites W2146849272 @default.
- W2018222564 cites W2154185970 @default.
- W2018222564 cites W2157873533 @default.
- W2018222564 cites W2158301564 @default.
- W2018222564 cites W2162210817 @default.
- W2018222564 doi "https://doi.org/10.1093/nar/gkm235" @default.
- W2018222564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904287" @default.
- W2018222564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17478514" @default.
- W2018222564 hasPublicationYear "2007" @default.
- W2018222564 type Work @default.
- W2018222564 sameAs 2018222564 @default.
- W2018222564 citedByCount "94" @default.
- W2018222564 countsByYear W20182225642012 @default.
- W2018222564 countsByYear W20182225642013 @default.
- W2018222564 countsByYear W20182225642014 @default.
- W2018222564 countsByYear W20182225642015 @default.
- W2018222564 countsByYear W20182225642016 @default.
- W2018222564 countsByYear W20182225642017 @default.
- W2018222564 countsByYear W20182225642018 @default.
- W2018222564 countsByYear W20182225642019 @default.
- W2018222564 countsByYear W20182225642020 @default.
- W2018222564 countsByYear W20182225642021 @default.
- W2018222564 countsByYear W20182225642022 @default.
- W2018222564 countsByYear W20182225642023 @default.
- W2018222564 crossrefType "journal-article" @default.
- W2018222564 hasAuthorship W2018222564A5024951732 @default.
- W2018222564 hasAuthorship W2018222564A5044936635 @default.
- W2018222564 hasAuthorship W2018222564A5066322160 @default.
- W2018222564 hasBestOaLocation W20182225641 @default.
- W2018222564 hasConcept C101762097 @default.
- W2018222564 hasConcept C104317684 @default.
- W2018222564 hasConcept C107824862 @default.
- W2018222564 hasConcept C150194340 @default.
- W2018222564 hasConcept C167625842 @default.
- W2018222564 hasConcept C193252679 @default.
- W2018222564 hasConcept C199216141 @default.
- W2018222564 hasConcept C24284526 @default.
- W2018222564 hasConcept C33987129 @default.
- W2018222564 hasConcept C3662595 @default.
- W2018222564 hasConcept C54355233 @default.
- W2018222564 hasConcept C552990157 @default.
- W2018222564 hasConcept C62944979 @default.
- W2018222564 hasConcept C70721500 @default.
- W2018222564 hasConcept C78458016 @default.
- W2018222564 hasConcept C86339819 @default.
- W2018222564 hasConcept C86803240 @default.
- W2018222564 hasConceptScore W2018222564C101762097 @default.
- W2018222564 hasConceptScore W2018222564C104317684 @default.
- W2018222564 hasConceptScore W2018222564C107824862 @default.
- W2018222564 hasConceptScore W2018222564C150194340 @default.
- W2018222564 hasConceptScore W2018222564C167625842 @default.
- W2018222564 hasConceptScore W2018222564C193252679 @default.
- W2018222564 hasConceptScore W2018222564C199216141 @default.
- W2018222564 hasConceptScore W2018222564C24284526 @default.