Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018226841> ?p ?o ?g. }
- W2018226841 endingPage "54" @default.
- W2018226841 startingPage "41" @default.
- W2018226841 abstract "Embryonic stem cells (ES cells), the pluripotent derivatives of the inner cell mass from blastocysts, have the capacity for unlimited growth, self-renewal and differentiation toward all types of somatic cells. Angiotensin II (Ang II), the most important effector peptide of the renin–angiotensin system, is also an angiogenesis factor. However, the potential impact of Ang II on ES cell differentiation is still unknown. In the present study, we have successfully induced the differentiation of ES cells into smooth muscle cells (SMCs) on collagen IV. Interestingly, incubation of ES cells with Ang II further promoted SMC differentiation from ES cells, which was abolished by prior treatment with Ang II type 1 (AT1) receptor antagonist losartan, but not Ang II type 2 (AT2) receptor antagonist PD123319. Moreover, we found that, in parallel with SMC specific-marker induction, the expression levels of phosphoAkt and NF-Kappa B (NF-κB) p50 were up-regulated by Ang II. Importantly, addition of phosphoinositide-3 kinase (PI3K) inhibitor LY294002 led to a marked inhibition of Ang II induced SMC specific markers, phosphoAkt and NF-κB p50 expression. Furthermore, NF-κB inhibitor BAY11-7082 can inhibit Ang II induced expression of SMC specific markers. Thus, we demonstrate for the first time that Ang II plays a promotive role in the stage of ES cell differentiation to SMCs through AT1 receptor. We further confirmed that PI3K/Akt signaling pathway and NF-κB play key roles in this process." @default.
- W2018226841 created "2016-06-24" @default.
- W2018226841 creator A5010520524 @default.
- W2018226841 creator A5019117674 @default.
- W2018226841 creator A5043168113 @default.
- W2018226841 creator A5049673416 @default.
- W2018226841 creator A5051241309 @default.
- W2018226841 creator A5062933959 @default.
- W2018226841 creator A5066716873 @default.
- W2018226841 creator A5068399979 @default.
- W2018226841 creator A5077716269 @default.
- W2018226841 creator A5080114976 @default.
- W2018226841 date "2013-01-01" @default.
- W2018226841 modified "2023-10-17" @default.
- W2018226841 title "Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB" @default.
- W2018226841 cites W1512987131 @default.
- W2018226841 cites W1516075858 @default.
- W2018226841 cites W1606473945 @default.
- W2018226841 cites W1863226311 @default.
- W2018226841 cites W1965883902 @default.
- W2018226841 cites W1980087524 @default.
- W2018226841 cites W1981606231 @default.
- W2018226841 cites W1983446204 @default.
- W2018226841 cites W1985014243 @default.
- W2018226841 cites W1985658116 @default.
- W2018226841 cites W1988871802 @default.
- W2018226841 cites W1989629208 @default.
- W2018226841 cites W1997520211 @default.
- W2018226841 cites W1998919881 @default.
- W2018226841 cites W1999009908 @default.
- W2018226841 cites W1999473143 @default.
- W2018226841 cites W2002283596 @default.
- W2018226841 cites W2005347754 @default.
- W2018226841 cites W2008087295 @default.
- W2018226841 cites W2008987764 @default.
- W2018226841 cites W2010296764 @default.
- W2018226841 cites W2012505976 @default.
- W2018226841 cites W2014575233 @default.
- W2018226841 cites W2020499012 @default.
- W2018226841 cites W2022334253 @default.
- W2018226841 cites W2025985350 @default.
- W2018226841 cites W2029291952 @default.
- W2018226841 cites W2029375287 @default.
- W2018226841 cites W2031955280 @default.
- W2018226841 cites W2033199439 @default.
- W2018226841 cites W2041792559 @default.
- W2018226841 cites W2046867705 @default.
- W2018226841 cites W2051332153 @default.
- W2018226841 cites W2053716402 @default.
- W2018226841 cites W2053901268 @default.
- W2018226841 cites W2056034929 @default.
- W2018226841 cites W2065631010 @default.
- W2018226841 cites W2066763521 @default.
- W2018226841 cites W2070133934 @default.
- W2018226841 cites W2073873260 @default.
- W2018226841 cites W2074499846 @default.
- W2018226841 cites W2083811543 @default.
- W2018226841 cites W2093548319 @default.
- W2018226841 cites W2094208472 @default.
- W2018226841 cites W2095686773 @default.
- W2018226841 cites W2096088261 @default.
- W2018226841 cites W2096318070 @default.
- W2018226841 cites W2104814355 @default.
- W2018226841 cites W2108645432 @default.
- W2018226841 cites W2111175065 @default.
- W2018226841 cites W2111413350 @default.
- W2018226841 cites W2111780029 @default.
- W2018226841 cites W2123511028 @default.
- W2018226841 cites W2123938685 @default.
- W2018226841 cites W2124166909 @default.
- W2018226841 cites W2127738953 @default.
- W2018226841 cites W2133543344 @default.
- W2018226841 cites W2134062610 @default.
- W2018226841 cites W2135919238 @default.
- W2018226841 cites W2137006009 @default.
- W2018226841 cites W2145091080 @default.
- W2018226841 cites W2148408888 @default.
- W2018226841 cites W2154139552 @default.
- W2018226841 cites W2157988179 @default.
- W2018226841 cites W2158020869 @default.
- W2018226841 cites W2166422999 @default.
- W2018226841 doi "https://doi.org/10.1016/j.diff.2012.11.003" @default.
- W2018226841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23337518" @default.
- W2018226841 hasPublicationYear "2013" @default.
- W2018226841 type Work @default.
- W2018226841 sameAs 2018226841 @default.
- W2018226841 citedByCount "23" @default.
- W2018226841 countsByYear W20182268412013 @default.
- W2018226841 countsByYear W20182268412015 @default.
- W2018226841 countsByYear W20182268412016 @default.
- W2018226841 countsByYear W20182268412017 @default.
- W2018226841 countsByYear W20182268412018 @default.
- W2018226841 countsByYear W20182268412019 @default.
- W2018226841 countsByYear W20182268412021 @default.
- W2018226841 countsByYear W20182268412022 @default.
- W2018226841 countsByYear W20182268412023 @default.
- W2018226841 crossrefType "journal-article" @default.
- W2018226841 hasAuthorship W2018226841A5010520524 @default.