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- W2018227523 abstract "NEPHROTIC SYNDROME in children is most commonly caused by minimal change disease, accounting for 90% of cases of nephrotic syndrome in those younger than 10 years. 1 The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone A report of the International Study of Kidney Disease in Children. J Pediatr. 1981; 98: 561-564 Abstract Full Text PDF PubMed Scopus (639) Google Scholar Even in adults, minimal change disease is responsible for a substantial proportion of cases of nephrotic syndrome, with a reported incidence varying between 10% and 15%. 2 Haas M. Meehan S.M. Karrison T.G. Spargo B.H. Changing etiologies of unexplained adult nephrotic syndrome A comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am J Kidney Dis. 1997; 30: 621-631 Abstract Full Text PDF PubMed Scopus (412) Google Scholar , 3 Nolasco F. Cameron J.S. Heywood E.F. et al. Adult-onset minimal change nephrotic syndrome A long-term follow-up. Kidney Int. 1986; 29: 1215-1223 Crossref PubMed Scopus (201) Google Scholar Steroids are the first line of treatment in both children and adults, inducing complete remission of nephrotic proteinuria in more than 90% of patients. 1 The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone A report of the International Study of Kidney Disease in Children. J Pediatr. 1981; 98: 561-564 Abstract Full Text PDF PubMed Scopus (639) Google Scholar Relapses of nephrotic syndrome after withdrawal of steroid therapy are another characteristic feature of minimal change disease. These relapses generally respond favorably to the reintroduction of steroid therapy. A minority of patients eventually develop steroid-dependent or steroid-resistant nephrotic syndrome, and in such patients, other diagnoses should be considered. The case of a patient who initially showed typical clinical and histopathologic features of minimal change disease and subsequently developed steroid-dependent nephrotic syndrome and microscopic hematuria is presented." @default.
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- W2018227523 title "A case of minimal change disease evolving into steroid-dependent nephrotic syndrome with hematuria" @default.
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