Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018228706> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2018228706 endingPage "738" @default.
- W2018228706 startingPage "733" @default.
- W2018228706 abstract "A human cell line, IFr, established from RSa cells, is a variant with increased resistance to cell proliferation inhibition (CPI) by human interferon (HuIFN)-α. The parent RSa cells are also hypermutable after irradiation with far-ultraviolet light (UV), as assessed by two different methods: cloning efficiency of ouabain-resistant (OuaR) mutants and K-ras codon 12 mutation in genomic DNA identified by polymerase chain reaction (PCR) following differential dot-blot hybridization. In the present study, IFr cells were found to be hypomutable: Less than 1 OuaR mutant per 104 surviving cells after UV (0-12 J/m2), in contrast to 1-53 OuaR mutants per 104 survivors in RSa cells, and no-detectable K-ras codon 12 mutation at any doses tested. However, IFr cells, when cultured with medium containing the protease inhibitor antipain after UV irradiation showed hypermutability to almost the same extent as RSa cells, as determined by both phenotypic and genetic mutation analyses. These results, together with the previous finding of antipain-sensitive protease induction in UV-irradiated or HuIFN-α-treated IFr cells, suggest that antipain-sensitive proteases or cellular functions or both may be involved in not only HuIFN-α resistance but also hypomutability of IFr cells." @default.
- W2018228706 created "2016-06-24" @default.
- W2018228706 creator A5025595716 @default.
- W2018228706 creator A5039391837 @default.
- W2018228706 creator A5058562018 @default.
- W2018228706 creator A5065846614 @default.
- W2018228706 creator A5075034711 @default.
- W2018228706 date "1996-09-01" @default.
- W2018228706 modified "2023-09-23" @default.
- W2018228706 title "Hypomutable Potential Accompanying Interferon-α Resistance in a Human Cell Line, IFr, Derived from Interferon-αSensitive and Hypermutable RSa Cells" @default.
- W2018228706 cites W1969648252 @default.
- W2018228706 cites W1973619328 @default.
- W2018228706 cites W1978104302 @default.
- W2018228706 cites W2008175811 @default.
- W2018228706 cites W2012137172 @default.
- W2018228706 cites W2025465903 @default.
- W2018228706 cites W2035037746 @default.
- W2018228706 cites W2056421415 @default.
- W2018228706 cites W2070069187 @default.
- W2018228706 cites W2080100976 @default.
- W2018228706 cites W2089519355 @default.
- W2018228706 cites W2141441260 @default.
- W2018228706 cites W2165371177 @default.
- W2018228706 doi "https://doi.org/10.1089/jir.1996.16.733" @default.
- W2018228706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8887058" @default.
- W2018228706 hasPublicationYear "1996" @default.
- W2018228706 type Work @default.
- W2018228706 sameAs 2018228706 @default.
- W2018228706 citedByCount "4" @default.
- W2018228706 crossrefType "journal-article" @default.
- W2018228706 hasAuthorship W2018228706A5025595716 @default.
- W2018228706 hasAuthorship W2018228706A5039391837 @default.
- W2018228706 hasAuthorship W2018228706A5058562018 @default.
- W2018228706 hasAuthorship W2018228706A5065846614 @default.
- W2018228706 hasAuthorship W2018228706A5075034711 @default.
- W2018228706 hasConcept C104317684 @default.
- W2018228706 hasConcept C121050878 @default.
- W2018228706 hasConcept C143065580 @default.
- W2018228706 hasConcept C153911025 @default.
- W2018228706 hasConcept C159047783 @default.
- W2018228706 hasConcept C181199279 @default.
- W2018228706 hasConcept C199360897 @default.
- W2018228706 hasConcept C2775883766 @default.
- W2018228706 hasConcept C2776178377 @default.
- W2018228706 hasConcept C2776714187 @default.
- W2018228706 hasConcept C2781378782 @default.
- W2018228706 hasConcept C41008148 @default.
- W2018228706 hasConcept C501734568 @default.
- W2018228706 hasConcept C54355233 @default.
- W2018228706 hasConcept C55493867 @default.
- W2018228706 hasConcept C81885089 @default.
- W2018228706 hasConcept C86803240 @default.
- W2018228706 hasConceptScore W2018228706C104317684 @default.
- W2018228706 hasConceptScore W2018228706C121050878 @default.
- W2018228706 hasConceptScore W2018228706C143065580 @default.
- W2018228706 hasConceptScore W2018228706C153911025 @default.
- W2018228706 hasConceptScore W2018228706C159047783 @default.
- W2018228706 hasConceptScore W2018228706C181199279 @default.
- W2018228706 hasConceptScore W2018228706C199360897 @default.
- W2018228706 hasConceptScore W2018228706C2775883766 @default.
- W2018228706 hasConceptScore W2018228706C2776178377 @default.
- W2018228706 hasConceptScore W2018228706C2776714187 @default.
- W2018228706 hasConceptScore W2018228706C2781378782 @default.
- W2018228706 hasConceptScore W2018228706C41008148 @default.
- W2018228706 hasConceptScore W2018228706C501734568 @default.
- W2018228706 hasConceptScore W2018228706C54355233 @default.
- W2018228706 hasConceptScore W2018228706C55493867 @default.
- W2018228706 hasConceptScore W2018228706C81885089 @default.
- W2018228706 hasConceptScore W2018228706C86803240 @default.
- W2018228706 hasIssue "9" @default.
- W2018228706 hasLocation W20182287061 @default.
- W2018228706 hasLocation W20182287062 @default.
- W2018228706 hasOpenAccess W2018228706 @default.
- W2018228706 hasPrimaryLocation W20182287061 @default.
- W2018228706 hasRelatedWork W1516061897 @default.
- W2018228706 hasRelatedWork W1871080937 @default.
- W2018228706 hasRelatedWork W2039515164 @default.
- W2018228706 hasRelatedWork W2150914257 @default.
- W2018228706 hasRelatedWork W2156423843 @default.
- W2018228706 hasRelatedWork W2156674132 @default.
- W2018228706 hasRelatedWork W2371897931 @default.
- W2018228706 hasRelatedWork W2374211041 @default.
- W2018228706 hasRelatedWork W2379610755 @default.
- W2018228706 hasRelatedWork W3140941569 @default.
- W2018228706 hasVolume "16" @default.
- W2018228706 isParatext "false" @default.
- W2018228706 isRetracted "false" @default.
- W2018228706 magId "2018228706" @default.
- W2018228706 workType "article" @default.