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- W2018237759 abstract "The molecular basis for the inhibitory action of the antiatopic drug, N-(3′,4′-dimethoxycinnamoyl)anthranilic acid (Tranilast), on the thrombin-induced release of a lysosomal enzyme, β-N-acetylglucosaminidase, from washed rabbit platelets was investigated. Tranilast dose dependently increased cyclic AMP and cyclic GMP levels in thrombin-stimulated platelets, parallel with the inhibition of β-N-acetylglucosaminidase release. There was no significant effect of Tranilast on adenylate or guanylate cyclase activity. Tranilast inhibited the activity of cyclic AMP and cyclic GMP phosphodiesterases in a cell-free system. The data suggest that the inhibitory action of Tranilast on the release reaction in platelets was due at least in part to inhibition of cyclic nucleotide phosphodiesterases followed by an elevation of cyclic AMP and cyclic GMP levels." @default.
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- W2018237759 date "1988-07-01" @default.
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- W2018237759 title "The mechanism for the inhibitory action of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (tranilast) on the release reaction in platelets" @default.
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- W2018237759 doi "https://doi.org/10.1016/0014-2999(88)90844-8" @default.
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