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• W2018239076 abstract "The α subunit of GTP-binding protein Golf (Gαolf), identified in the olfactory epithelium, in which it is supposed to mediate odorant-generated adenylyl cyclase activations, is much more expressed in the striatum than Gαs, the classical stimulatory G protein α subunit (Herve´et al., J Neurosci., 13 (1993) 2237–2248). Four species of Gαolf messenger RNA (mRNA) were observed by Northern blot in the rat striatum. Analysis of striatal Gαolf cDNA clones demonstrated that despite extensive variations in their 5′ and 3′ untranslated regions, these four Gαolf mRNAs encode the same Gaolf polypeptide. One of the four mRNA species, which was selectively observed in the striatum, is generated by a novel promoter whose activity was barely detectable in the olfactory epithelium. Surprisingly, this promoter generates an unexpectedly high proportion of transcripts in which the first intron is unspliced. The retention of intron was found to abolish the translation of Gαolf mRNA in the reticulocyte lysate system, suggesting that it could be involved in the down regulation of Gαolf expression in the striatum. Furthermore, a new polyadenylation site with the non canonical sequence, AATACA, was found to be responsible of the two shortest forms of Gαolf mRNA. In conclusion, we have shown that the Gaolf proteins present in the striatum and the olfactory epithelium are identical and that multiple variations in the untranslated parts of the mRNAs could affect Gαolf expression." @default.
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• W2018239076 date "1995-08-01" @default.
• W2018239076 modified "2023-09-25" @default.
• W2018239076 title "Molecular analysis of the multiple Golf α subunit mRNAs in the rat brain" @default.
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• W2018239076 doi "https://doi.org/10.1016/0169-328x(95)00070-9" @default.
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