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- W2018239968 abstract "Three 18 F labeled fluoronitroimidazoles have been prepared as potential in vivo markers of hypoxic cells in tumors, and ischemic areas of the heart and brain. 1-(2-Nitroimidazolyl)-3-[ 18 F]fluoro-2-hydroxypropanol ( 18 F]fluoro-normethoxymisonidazole) 4 , 1-(2-[ 18 F]fluoroethyl)-2-nitroimidazole 7 , and 1-(2-[ 18 F]fluoroethyl)-2-methyl-5-nitroimidazole ([ 18 F]fluoro-norhydroxymetronidazole) 10 were prepared in average radiochemical yields of <1%, 23% and 15–43% (8% at the no carrier-added level) respectively at end-of-synthesis. The in vivo biodistribution in rats was determined for each of the 18 F labeled fluoronitroimidazoles. At 1 and 3 h after administration, the tissue distribution of each of the 18 F labeled nitroimidzaoles was quite uniform and consistent with that of nitroimidazoles previously studied. These results suggest the need for a suitable animal model to evaluate their potential as in vivo markers of hypoxic tissue in the brain." @default.
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- W2018239968 title "Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: Potential in vivo markers of hypoxic tissue" @default.
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- W2018239968 doi "https://doi.org/10.1016/0883-2889(86)90079-1" @default.
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