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- W2018243518 abstract "It has long been obvious that the two ovarian hormones estrogen and progesterone have a definite relationship to each other and to menstrual and reproductive function. An antagonistic relationship between estrogen and progesterone was first suggested by Smith and Smith in 1931 (1). Prior to the presentation of a gravimetric method for the estimation of urinary pregnandiol by Venning (2) in 1937, endometrial biopsy was the only means available for the estimation of progesterone activity. Wilson, Randall and Osterberg (3) have presented evidence indicating that endometrial changes do not provide an accurate index to the variations of urinary pregnandiol levels. This observation would seem to indicate that endometrial changes are of qualitative rather than quantitative significance. Lack of quantitative means for the determination of progesterone activity has undoubtedly been responsible for the paucity of considerations of estrogen and progesterone relationship in the literature. Theories for estrogen and p..." @default.
- W2018243518 created "2016-06-24" @default.
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- W2018243518 date "1942-02-01" @default.
- W2018243518 modified "2023-09-27" @default.
- W2018243518 title "Subjective Symptoms and Therapeutic Response in the Control of Estrogen-Progesterone Therapy in Menstrual and Reproductive Disorders" @default.
- W2018243518 doi "https://doi.org/10.1210/jcem-2-2-120" @default.
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