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• W2018250384 endingPage "919" @default.
• W2018250384 startingPage "914" @default.
• W2018250384 abstract "Abstract Developing assays to detect endocrine‐mediated toxicity from in ovo or in utero exposure is a current challenge in regulatory toxicology. Some species of reptiles exhibiting a unique mode of sex determination, in which the incubation temperature during a critical period determines gonadal sex, have been explored as an in ovo model to screen environmental contaminants for endocrine effects. We critically review published egg‐exposure studies and conclude that data regarding the pharmacokinetics of topically applied substances are insufficient to validate dose—response relationships for the effects of chemicals on in ovo endocrine function or gender determination in reptiles. The insufficiencies in these data largely result from methodological failures, including lack of measurement verification, failure to investigate and control extraneous factors affecting the measurements, and lack of independent replication of results. Considerable additional research will be necessary to alleviate these methodological inadequacies. Given the current status of the data, topical treatment of reptilian eggs cannot be considered to be a valid means of establishing causal relationships between chemical treatment and biological outcome." @default.
• W2018250384 created "2016-06-24" @default.
• W2018250384 creator A5002483192 @default.
• W2018250384 creator A5007835466 @default.
• W2018250384 creator A5047352916 @default.
• W2018250384 date "2007-05-01" @default.
• W2018250384 modified "2023-10-16" @default.
• W2018250384 title "TOPICAL DOSE DELIVERY IN THE REPTILIAN EGG TREATMENT MODEL" @default.
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