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- W2018250462 abstract "Purpose: To develop principal component analysis (PCA) models from daily cone beam CTs (CBCTs) of head and neck (H&N) patients that could be used prospectively in adaptive radiation therapy (ART). Methods: : For 7 H&N patients, Pinnacle Treatment Planning System (Philips Healthcare) was used to retrospectively deformably register daily CBCTs to the planning CT. The number N of CBCTs per treatment course ranged from 14 to 22. For each patient a PCA model was built from the deformation vector fields (DVFs), after first subtracting the mean DVF, producing N eigen-DVFs (EDVFs). It was hypothesized that EDVFs with large eigenvalues represent the major anatomical deformations during the course of treatment, and that it is feasible to relate each EDVF to a clinically meaningful systematic or random change in anatomy, such as weight loss, neck flexion, etc. Results: DVFs contained on the order of 3×87×87×58=1.3 million scalar values (3 times the number of voxels in the registered volume). The top 3 eigenvalues accounted for ∼90% of variance. Anatomical changes corresponding to an EDVF were evaluated by generating a synthetic DVF, and applying that DVF to the CT to produce a synthetic CBCT. For all patients, the EDVF for the largest eigenvalue was interpreted to model weight loss. The EDVF for other eigenvalues appeared to represented quasi-random fraction-to-fraction changes. Conclusion: The leading EDVFs from single-patient PCA models have tentatively been identified with weight loss changes during treatment. Other EDVFs are tentatively identified as quasi-random inter-fraction changes. Clean separation of systematic and random components may require further work. This work is expected to facilitate development of population-based PCA models that can be used to prospectively identify significant anatomical changes, such as weight loss, early in treatment, triggering replanning where beneficial." @default.
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- W2018250462 date "2014-05-29" @default.
- W2018250462 modified "2023-09-26" @default.
- W2018250462 title "SU-C-BRF-03: PCA Modeling of Anatomical Changes During Head and Neck Radiation Therapy" @default.
- W2018250462 doi "https://doi.org/10.1118/1.4889723" @default.
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