Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018254691> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2018254691 endingPage "104" @default.
- W2018254691 startingPage "101" @default.
- W2018254691 abstract "Graft rejection is the major cause of failure of HLA mismatched bone marrow transplantation because of residual host immunity. we have proposed to use a monoclonal murine antibody specific for the LFA-1 molecule (25-3) to prevent graft failure in HLA mismatched bone marrow transplantation (BMT). The rationale for this approach is three fold: LFA-1 deficient patients (3/3) do not reject HLA mismatched BMT; anti LFA-1 blocka in vitro the induction of T cell responses and T/ non T cytotoxic functions; LFA-1 is not expressed by other cells than leucocytes. We have accordingly treated twenty two patients with inherited diseases and 8 with leikemia. The bone marrow was T cells depled by E rosetting of Campath antibody. The antibody was given at days -3, -1, +1, +3, +5 at dose of .1 mg/kg/d for the first 9 and then .2mg/kg/d from day -3 to +6. Engraftment occured in 23/30 patients as shown by at least HLA typing. Hematological recovery was rapid, GVH was limited. Side effects of antibody infusion included fever and possibly an increased incidence of early bacteral infection (sepsis, 1 death). Immunological reconstitution occured slowly leading in six cases to EBV-induced B cell poliferation (1 death and in two others to transient auto immune hemolytic anemia. There has been only one secondary graft rejection. Sisteen patients are alive 3 to 26 months post transplant with functional grafts. Although the number of patients treated is still low the absence of late rejection so far, gives hope for long term maintenance of the graft using anti LFA-1. Since the antibody is an IgG 1 unable to bind human complement, and since it is known to inhibit phagocytosis, there is a good suggestion that 25-3 act through functional blocking of host T and non T luymphocytes at both induction and effector levels." @default.
- W2018254691 created "2016-06-24" @default.
- W2018254691 creator A5006297452 @default.
- W2018254691 creator A5029004287 @default.
- W2018254691 creator A5029679351 @default.
- W2018254691 creator A5032703463 @default.
- W2018254691 creator A5050476088 @default.
- W2018254691 creator A5051621566 @default.
- W2018254691 creator A5063987135 @default.
- W2018254691 creator A5088698359 @default.
- W2018254691 date "1987-01-01" @default.
- W2018254691 modified "2023-10-16" @default.
- W2018254691 title "Prevention of bone marrow graft failure by an anti LFA-1 monoclonal antibody" @default.
- W2018254691 doi "https://doi.org/10.1590/s0074-02761987000600015" @default.
- W2018254691 hasPublicationYear "1987" @default.
- W2018254691 type Work @default.
- W2018254691 sameAs 2018254691 @default.
- W2018254691 citedByCount "0" @default.
- W2018254691 crossrefType "journal-article" @default.
- W2018254691 hasAuthorship W2018254691A5006297452 @default.
- W2018254691 hasAuthorship W2018254691A5029004287 @default.
- W2018254691 hasAuthorship W2018254691A5029679351 @default.
- W2018254691 hasAuthorship W2018254691A5032703463 @default.
- W2018254691 hasAuthorship W2018254691A5050476088 @default.
- W2018254691 hasAuthorship W2018254691A5051621566 @default.
- W2018254691 hasAuthorship W2018254691A5063987135 @default.
- W2018254691 hasAuthorship W2018254691A5088698359 @default.
- W2018254691 hasBestOaLocation W20182546911 @default.
- W2018254691 hasConcept C126322002 @default.
- W2018254691 hasConcept C147483822 @default.
- W2018254691 hasConcept C154317977 @default.
- W2018254691 hasConcept C159654299 @default.
- W2018254691 hasConcept C188280979 @default.
- W2018254691 hasConcept C202751555 @default.
- W2018254691 hasConcept C203014093 @default.
- W2018254691 hasConcept C2778384902 @default.
- W2018254691 hasConcept C2780007613 @default.
- W2018254691 hasConcept C2911091166 @default.
- W2018254691 hasConcept C542903549 @default.
- W2018254691 hasConcept C55493867 @default.
- W2018254691 hasConcept C71924100 @default.
- W2018254691 hasConcept C86803240 @default.
- W2018254691 hasConcept C8891405 @default.
- W2018254691 hasConceptScore W2018254691C126322002 @default.
- W2018254691 hasConceptScore W2018254691C147483822 @default.
- W2018254691 hasConceptScore W2018254691C154317977 @default.
- W2018254691 hasConceptScore W2018254691C159654299 @default.
- W2018254691 hasConceptScore W2018254691C188280979 @default.
- W2018254691 hasConceptScore W2018254691C202751555 @default.
- W2018254691 hasConceptScore W2018254691C203014093 @default.
- W2018254691 hasConceptScore W2018254691C2778384902 @default.
- W2018254691 hasConceptScore W2018254691C2780007613 @default.
- W2018254691 hasConceptScore W2018254691C2911091166 @default.
- W2018254691 hasConceptScore W2018254691C542903549 @default.
- W2018254691 hasConceptScore W2018254691C55493867 @default.
- W2018254691 hasConceptScore W2018254691C71924100 @default.
- W2018254691 hasConceptScore W2018254691C86803240 @default.
- W2018254691 hasConceptScore W2018254691C8891405 @default.
- W2018254691 hasIssue "suppl 2" @default.
- W2018254691 hasLocation W20182546911 @default.
- W2018254691 hasLocation W20182546912 @default.
- W2018254691 hasOpenAccess W2018254691 @default.
- W2018254691 hasPrimaryLocation W20182546911 @default.
- W2018254691 hasRelatedWork W1530343147 @default.
- W2018254691 hasRelatedWork W1602847563 @default.
- W2018254691 hasRelatedWork W1991697133 @default.
- W2018254691 hasRelatedWork W1997716688 @default.
- W2018254691 hasRelatedWork W2008949385 @default.
- W2018254691 hasRelatedWork W2038126255 @default.
- W2018254691 hasRelatedWork W2053177727 @default.
- W2018254691 hasRelatedWork W2064089409 @default.
- W2018254691 hasRelatedWork W2220102944 @default.
- W2018254691 hasRelatedWork W4287378939 @default.
- W2018254691 hasVolume "82" @default.
- W2018254691 isParatext "false" @default.
- W2018254691 isRetracted "false" @default.
- W2018254691 magId "2018254691" @default.
- W2018254691 workType "article" @default.