FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018259775> ?p ?o ?g. }

• W2018259775 endingPage "641" @default.
• W2018259775 startingPage "633" @default.
• W2018259775 abstract "We investigated the role of the hematopoietically expressed homeobox (Hex) in the differentiation and development of hepatocytes within embryonic stem cell (ESC)–derived embryoid bodies (EBs). Analyses of hepatic endoderm derived from Hex−/− EBs revealed a dramatic reduction in the levels of albumin (Alb) and alpha-fetoprotein (Afp) expression. In contrast, stage-specific forced expression of Hex in EBs from wild-type ESCs led to the up-regulation of Alb and Afp expression and secretion of Alb and transferrin. These inductive effects were restricted to c-kit+ endoderm-enriched EB-derived populations, suggesting that Hex functions at the level of hepatic specification of endoderm in this model. Microarray analysis revealed that Hex regulated the expression of a broad spectrum of hepatocyte-related genes, including fibrinogens, apolipoproteins, and cytochromes. When added to the endoderm-induced EBs, bone morphogenetic protein 4 acted synergistically with Hex in the induction of expression of Alb, Afp, carbamoyl phosphate synthetase, transcription factor 1, and CCAAT/enhancer binding protein α. These findings indicate that Hex plays a pivotal role during induction of liver development from endoderm in this in vitro model and suggest that this strategy may provide important insight into the generation of functional hepatocytes from ESCs. (HEPATOLOGY 2010.)" @default.
• W2018259775 created "2016-06-24" @default.
• W2018259775 creator A5006421923 @default.
• W2018259775 creator A5021860620 @default.
• W2018259775 creator A5031853100 @default.
• W2018259775 creator A5035319682 @default.
• W2018259775 creator A5036956529 @default.
• W2018259775 creator A5039196893 @default.
• W2018259775 creator A5055939622 @default.
• W2018259775 creator A5058967771 @default.
• W2018259775 creator A5066956159 @default.
• W2018259775 creator A5073820121 @default.
• W2018259775 creator A5080548800 @default.
• W2018259775 date "2009-09-09" @default.
• W2018259775 modified "2023-10-04" @default.
• W2018259775 title "The homeobox gene<i>Hex</i>regulates hepatocyte differentiation from embryonic stem cell-derived endoderm" @default.
• W2018259775 cites W1965486761 @default.
• W2018259775 cites W1972139648 @default.
• W2018259775 cites W1979145849 @default.
• W2018259775 cites W1988345591 @default.
• W2018259775 cites W1991664409 @default.
• W2018259775 cites W1996498993 @default.
• W2018259775 cites W1997732519 @default.
• W2018259775 cites W2004196170 @default.
• W2018259775 cites W2005729329 @default.
• W2018259775 cites W2023749098 @default.
• W2018259775 cites W2025596234 @default.
• W2018259775 cites W2033791639 @default.
• W2018259775 cites W2045742275 @default.
• W2018259775 cites W2055392065 @default.
• W2018259775 cites W2057760613 @default.
• W2018259775 cites W2059215767 @default.
• W2018259775 cites W2083165947 @default.
• W2018259775 cites W2103588034 @default.
• W2018259775 cites W2108946209 @default.
• W2018259775 cites W2111888351 @default.
• W2018259775 cites W2112246274 @default.
• W2018259775 cites W2117969708 @default.
• W2018259775 cites W2120060713 @default.
• W2018259775 cites W2132556256 @default.
• W2018259775 cites W2137424064 @default.
• W2018259775 cites W2139020188 @default.
• W2018259775 cites W2142362599 @default.
• W2018259775 cites W2143973293 @default.
• W2018259775 cites W2168967248 @default.
• W2018259775 cites W2169656634 @default.
• W2018259775 cites W3021092633 @default.
• W2018259775 doi "https://doi.org/10.1002/hep.23293" @default.
• W2018259775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20063280" @default.
• W2018259775 hasPublicationYear "2009" @default.
• W2018259775 type Work @default.
• W2018259775 sameAs 2018259775 @default.
• W2018259775 citedByCount "39" @default.
• W2018259775 countsByYear W20182597752012 @default.
• W2018259775 countsByYear W20182597752013 @default.
• W2018259775 countsByYear W20182597752014 @default.
• W2018259775 countsByYear W20182597752015 @default.
• W2018259775 countsByYear W20182597752016 @default.
• W2018259775 countsByYear W20182597752018 @default.
• W2018259775 countsByYear W20182597752019 @default.
• W2018259775 countsByYear W20182597752020 @default.
• W2018259775 countsByYear W20182597752021 @default.
• W2018259775 countsByYear W20182597752022 @default.
• W2018259775 countsByYear W20182597752023 @default.
• W2018259775 crossrefType "journal-article" @default.
• W2018259775 hasAuthorship W2018259775A5006421923 @default.
• W2018259775 hasAuthorship W2018259775A5021860620 @default.
• W2018259775 hasAuthorship W2018259775A5031853100 @default.
• W2018259775 hasAuthorship W2018259775A5035319682 @default.
• W2018259775 hasAuthorship W2018259775A5036956529 @default.
• W2018259775 hasAuthorship W2018259775A5039196893 @default.
• W2018259775 hasAuthorship W2018259775A5055939622 @default.
• W2018259775 hasAuthorship W2018259775A5058967771 @default.
• W2018259775 hasAuthorship W2018259775A5066956159 @default.
• W2018259775 hasAuthorship W2018259775A5073820121 @default.
• W2018259775 hasAuthorship W2018259775A5080548800 @default.
• W2018259775 hasBestOaLocation W20182597751 @default.
• W2018259775 hasConcept C104317684 @default.
• W2018259775 hasConcept C107459253 @default.
• W2018259775 hasConcept C121587040 @default.
• W2018259775 hasConcept C143948831 @default.
• W2018259775 hasConcept C145103041 @default.
• W2018259775 hasConcept C153911025 @default.
• W2018259775 hasConcept C202751555 @default.
• W2018259775 hasConcept C2776200302 @default.
• W2018259775 hasConcept C2777164004 @default.
• W2018259775 hasConcept C54355233 @default.
• W2018259775 hasConcept C86339819 @default.
• W2018259775 hasConcept C86803240 @default.
• W2018259775 hasConcept C95444343 @default.
• W2018259775 hasConceptScore W2018259775C104317684 @default.
• W2018259775 hasConceptScore W2018259775C107459253 @default.
• W2018259775 hasConceptScore W2018259775C121587040 @default.
• W2018259775 hasConceptScore W2018259775C143948831 @default.
• W2018259775 hasConceptScore W2018259775C145103041 @default.
• W2018259775 hasConceptScore W2018259775C153911025 @default.
• W2018259775 hasConceptScore W2018259775C202751555 @default.
• W2018259775 hasConceptScore W2018259775C2776200302 @default.

• next