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- W2018261520 abstract "The murine immune response to Escherichia coli exposed to subminimal inhibitory concentrations offour antibiotics was investigated. Groups of mice were injected for 8 weeks with formalin-killed bacteria and subsequently challenged with 10 × LD50 of viable E. coli. Mice receiving saline only (controls) died within 24 h. The mortality of mice immunized with ciproftoxacin-treated E. coli was significantly lower than that of mice immunized with E. coli untreated or treated with other antibiotics, Sera from mice immunized with ciproftoxacin-treated bacteria showed better bacteriostatic capacity and enhanced production of antibodies that bound to homologous and heterologous lipopolysaccharide isolated from several smooth and rough gram-negative strains. The better protection observed in mice immunized with ciproftoxacin-treated E. coli was probably due to an enhanced production of antibodies to epitopes on lipopolysaccharide that became better exposed and so more accessible after treatment with ciproftoxacin." @default.
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- W2018261520 date "1991-01-01" @default.
- W2018261520 modified "2023-09-28" @default.
- W2018261520 title "Immunization of Mice with Antibiotic-Treated Escherichia coli Results in Enhanced Protection against Challenge with Homologous and Heterologous Bacteria" @default.
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- W2018261520 doi "https://doi.org/10.1093/infdis/163.1.122" @default.
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