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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018262244> ?p ?o ?g. }

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• W2018262244 startingPage "120" @default.
• W2018262244 abstract "The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by ∼60%. The longevity of clk-1 , daf-2 , daf-12 , and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension." @default.
• W2018262244 created "2016-06-24" @default.
• W2018262244 creator A5043884563 @default.
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• W2018262244 date "2002-01-04" @default.
• W2018262244 modified "2023-10-03" @default.
• W2018262244 title "Extension of Life-Span in <i>Caenorhabditis elegans</i> by a Diet Lacking Coenzyme Q" @default.
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• W2018262244 doi "https://doi.org/10.1126/science.1064653" @default.
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