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- W2018262679 abstract "Abstract Human bioavailability of the flavonoid dihydrochalcones is little understood, and no evidence exists for C ‐glycosyl flavonoid absorption in humans. The present study uses catechol‐ O ‐methyltransferase to generate methylated metabolites of aspalathin (a C ‐glycosyl dihydrochalcone from rooibos tea). One of the methylated forms, both with and without glucuronidation, was detected using LC‐MS/MS in the urine of human subjects ( n = 6), demonstrating that deglycosylation is not a prerequisite for C ‐glycosyl flavonoid absorption. Methylation is catalysed by both intestine and liver cytosolic extracts. The results show that flavonoid C ‐glycosides are methylated and glucuronidated in vivo in an intact form in humans." @default.
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- W2018262679 title "The <i>C</i> -glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans" @default.
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- W2018262679 doi "https://doi.org/10.1002/mnfr.200800569" @default.
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