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• W2018263025 startingPage "669" @default.
• W2018263025 abstract "Perinatal hypoxia–ischemia (HI) results in brain injury, whereas mild hypoxic episodes result in preconditioning, which can significantly reduce the vulnerability of the brain to subsequent severe hypoxia–ischemia. Hypoxic-preconditioning (PC) has been shown to enhance cell survival and differentiation of progenitor cells in the central nervous system (CNS). The purpose of this study was to determine whether pretreatment with PC prior to HI stimulates subventricular zone (SVZ) proliferation and neurogenesis in newborn piglets. One-day-old piglets were subjected to PC (8% O 2 /92% N 2 ) for 3 h and 24 h later were exposed to HI produced by combination of hypoxia (5% FiO 2 ) for a pre-defined period of 30 min and ischemia induced by a period of 10 min of hypotension. Here we demonstrate that SVZ derived neural stem/progenitor cells (NSPs) from PC, HI and PC + HI piglets proliferated as neurospheres, expressed neural progenitor and neurodevelopmental markers, and that greater proportion of the spheres generated are multipotential. Neurosphere assay revealed that preconditioning pretreatment increased the number of NSP-derived neurospheres in SVZ following HI compared to normoxic and HI controls. NSPs from preconditioned SVZ generated twice as many neurons and astrocytes in vitro . Injections with 5-Bromo-2-deoxyuridine (BrdU) after PC revealed a robust proliferative response within the SVZ that continued for one week. PC also increased neurogenesis in vivo , doublecortin positive cells with migratory profiles were observed streaming from the SVZ to striatum and neocortex. These findings show that the induction of proliferation and neurogenesis by PC might be a positive adaptation for an efficient repair and plasticity in the event of a hypoxic–ischemic insult. • Preconditioning increases the number of neurospheres in SVZ of newborn piglet brain. • Neural stem cells from preconditioned SVZ generate more neurons and astrocytes. • Preconditioning and hypoxia–ischemia following preconditioning increases proliferation. • Preconditioning augments the increase in neurogenesis in the post-hypoxic–ischemic brain." @default.
• W2018263025 created "2016-06-24" @default.
• W2018263025 creator A5063070414 @default.
• W2018263025 creator A5080453673 @default.
• W2018263025 date "2013-09-01" @default.
• W2018263025 modified "2023-09-30" @default.
• W2018263025 title "Hypoxic-preconditioning enhances the regenerative capacity of neural stem/progenitors in subventricular zone of newborn piglet brain" @default.
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• W2018263025 doi "https://doi.org/10.1016/j.scr.2013.04.007" @default.
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