Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018267504> ?p ?o ?g. }
- W2018267504 endingPage "243" @default.
- W2018267504 startingPage "238" @default.
- W2018267504 abstract "Curcumin is the principal element of turmeric powder extracted from the root of Curcuma longa. Studies on curcumin have demonstrated some anti-Helicobacter pylori activity as well as immunomodulating properties. N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H. pylori eradication therapy.To determine if a 7-day non-antibiotic therapy comprised of curcumin, lactoferrin, N-acetylcysteine, and pantoprazole was effective for eradication of H. pylori infection and reduction of gastric inflammation, assessed by serum pepsinogens and relief of symptoms.Twenty-five consecutive H. pylori-positive patients (12 males, mean age 50 +/- 12 years, range 31-76) with functional dyspepsia were enrolled. Patients were administered for 7 days curcumin 30 mg b.i.d., bovine lactoferrin 100 mg b.i.d., N-acetylcysteine 600 mg b.i.d., and pantoprazole 20 mg b.i.d. H. pylori status and upper gastrointestinal symptoms were assessed by (13)C-urea breath test and a scale of upper gastrointestinal symptoms intensity (absent, mild, moderate, and severe), as well as a blood test for serum pepsinogens (sPGI, sPGII), gastrin-17 (G-17), and anti-H. pylori IgG (IgG-Hp) at baseline (T0) and after 2 months (T1).Three of 25 patients (12%) were cured of H. pylori infection. A significant decrease in the overall severity of symptoms (T0: 6, interquartile range [IQR]: 4.5-8; T1: 2, IQR: 2-3; p < or = .001), and sPGII (T0: 16 microg/L, IQR: 13-22; T1: 10 microg/L, IQR: 8-16; p < or = .001) and sPGI (T0: 82 microg/L, IQR: 67-97; T1: 74 microg/L, IQR: 62-94; p = .02) levels were observed after 2 months of the treatment. IgG and G-17 values did not significantly decrease after 2 months.This novel therapy was not effective for H. pylori eradication. However, despite the bacterium persistence, significant improvement of dyspeptic symptoms and reduction of serologic signs of gastric inflammation were observed after 2 months at the end of the 7-day treatment schedule." @default.
- W2018267504 created "2016-06-24" @default.
- W2018267504 creator A5001722887 @default.
- W2018267504 creator A5002281246 @default.
- W2018267504 creator A5004434776 @default.
- W2018267504 creator A5013907113 @default.
- W2018267504 creator A5021006462 @default.
- W2018267504 creator A5023954560 @default.
- W2018267504 creator A5032927697 @default.
- W2018267504 creator A5035028725 @default.
- W2018267504 creator A5037832760 @default.
- W2018267504 creator A5046170185 @default.
- W2018267504 creator A5051533325 @default.
- W2018267504 creator A5056480185 @default.
- W2018267504 creator A5069863725 @default.
- W2018267504 creator A5077601354 @default.
- W2018267504 creator A5085147922 @default.
- W2018267504 date "2007-06-01" @default.
- W2018267504 modified "2023-10-16" @default.
- W2018267504 title "A Curcumin-Based 1-Week Triple Therapy for Eradication of Helicobacter pylori Infection: Something to Learn From Failure?" @default.
- W2018267504 cites W140788451 @default.
- W2018267504 cites W146555278 @default.
- W2018267504 cites W1482486740 @default.
- W2018267504 cites W1503398292 @default.
- W2018267504 cites W1511198581 @default.
- W2018267504 cites W1527988408 @default.
- W2018267504 cites W1923600385 @default.
- W2018267504 cites W1964232812 @default.
- W2018267504 cites W1967103313 @default.
- W2018267504 cites W1977290655 @default.
- W2018267504 cites W1978598856 @default.
- W2018267504 cites W1979278926 @default.
- W2018267504 cites W1982183146 @default.
- W2018267504 cites W1982486909 @default.
- W2018267504 cites W1982997073 @default.
- W2018267504 cites W1986258565 @default.
- W2018267504 cites W1986863380 @default.
- W2018267504 cites W1995804072 @default.
- W2018267504 cites W1997614694 @default.
- W2018267504 cites W2014524132 @default.
- W2018267504 cites W2021798461 @default.
- W2018267504 cites W2022948175 @default.
- W2018267504 cites W2023747518 @default.
- W2018267504 cites W2033431239 @default.
- W2018267504 cites W2039295918 @default.
- W2018267504 cites W2040378648 @default.
- W2018267504 cites W2040664792 @default.
- W2018267504 cites W2043505425 @default.
- W2018267504 cites W2044826456 @default.
- W2018267504 cites W2045324074 @default.
- W2018267504 cites W2048635128 @default.
- W2018267504 cites W2049146012 @default.
- W2018267504 cites W2050781058 @default.
- W2018267504 cites W2053031729 @default.
- W2018267504 cites W2061578496 @default.
- W2018267504 cites W2068211236 @default.
- W2018267504 cites W2069508138 @default.
- W2018267504 cites W2071957690 @default.
- W2018267504 cites W2081419858 @default.
- W2018267504 cites W2095318950 @default.
- W2018267504 cites W2095862261 @default.
- W2018267504 cites W2104366469 @default.
- W2018267504 cites W2109342699 @default.
- W2018267504 cites W2115841218 @default.
- W2018267504 cites W2134742719 @default.
- W2018267504 cites W2136210283 @default.
- W2018267504 cites W2139716135 @default.
- W2018267504 cites W2141909270 @default.
- W2018267504 cites W2146962477 @default.
- W2018267504 cites W2157067671 @default.
- W2018267504 cites W2330377215 @default.
- W2018267504 cites W4245896531 @default.
- W2018267504 doi "https://doi.org/10.1111/j.1523-5378.2007.00497.x" @default.
- W2018267504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17493004" @default.
- W2018267504 hasPublicationYear "2007" @default.
- W2018267504 type Work @default.
- W2018267504 sameAs 2018267504 @default.
- W2018267504 citedByCount "109" @default.
- W2018267504 countsByYear W20182675042012 @default.
- W2018267504 countsByYear W20182675042013 @default.
- W2018267504 countsByYear W20182675042014 @default.
- W2018267504 countsByYear W20182675042015 @default.
- W2018267504 countsByYear W20182675042016 @default.
- W2018267504 countsByYear W20182675042017 @default.
- W2018267504 countsByYear W20182675042018 @default.
- W2018267504 countsByYear W20182675042019 @default.
- W2018267504 countsByYear W20182675042020 @default.
- W2018267504 countsByYear W20182675042021 @default.
- W2018267504 countsByYear W20182675042022 @default.
- W2018267504 countsByYear W20182675042023 @default.
- W2018267504 crossrefType "journal-article" @default.
- W2018267504 hasAuthorship W2018267504A5001722887 @default.
- W2018267504 hasAuthorship W2018267504A5002281246 @default.
- W2018267504 hasAuthorship W2018267504A5004434776 @default.
- W2018267504 hasAuthorship W2018267504A5013907113 @default.
- W2018267504 hasAuthorship W2018267504A5021006462 @default.
- W2018267504 hasAuthorship W2018267504A5023954560 @default.
- W2018267504 hasAuthorship W2018267504A5032927697 @default.