FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018269715> ?p ?o ?g. }

• W2018269715 endingPage "S185" @default.
• W2018269715 startingPage "S185" @default.
• W2018269715 abstract "Cardiovascular parameters such as arterial blood pressure (ABP) and heart rate display pronounced circadian variation. In addition, evidence has been presented in favor of diurnal changes of perfusion in the heart, skin, kidney, and skeletal muscle. The present study was performed to detect whether there is a circadian periodicity in the regulation of cerebral perfusion. Normotensive Sprague Dawley rats (SDR, appr. 15 weeks old) and hypertensive (mREN2)27 transgenic rats (TGR, approximately 12 weeks old) were equipped in the abdominal aorta with a blood pressure sensor coupled to a telemetry system for continuous recording of systolic and diastolic ABP, heart rate, and locomotor activity. Five to twelve days later, a laser-Doppler flowmetry (LDF) probe was attached to the skull by means of a guiding device to measure changes of cerebral blood flow (CBF). After recovery from anesthesia, continuous measurements were taken for 3–5 days. The time series were analyzed with respect to the MESOR (midline estimating statistic of rhythm, i.e. the mean value of a given period), amplitude, and acrophase (i.e. the phase angle corresponding to the peak of a given period) of the 24 h period and subharmonics including 12 h, 8 h, 4.8 h and 4 h period length. All data are given as meanSD with the time indicated in 24 h format. The circadian rhythm was the most prominent one for each parameter throughout the experiments. In SDR the acrophases of systolic and diastolic ABP were at 04:12 h 42 min and 02:24 h 42 min, respectively. In the TGR the ABP signal showed its typical inverse pattern with the maximum of the ABP occurring during light on (acrophase of systolic ABP, 09:48 h 108 min; acrophase of diastolic ABP, 09:54 h 144 min), i.e. during the resting phase of the animals. The peak of the circadian periodicity in the LDF signal occurred around midnight in both, SDR (23:54 h 114 min) and TGR (00:48 h 78 min), i.e. during the subjective activity phase of the animals. The acrophase position of the LDF signal was consistently prior to that of the locomotor activity (SDR, 01:42 h 18 min; TGR, 1:18 h 66 min). The present data suggest the presence of a circadian periodicity in the regulation of cerebral perfusion. The generator of this periodicity is not yet known. The circadian rhythm in the LDF signal is independent from that of the ABP since it did not follow the inverse periodicity in TGR. It is probably also independent from locomotor activity since its peak occurred consistently prior to that of the locomotor activity. The presence of a circadian periodicity in the CBF may have implications for the occurrence of diurnal alterations of cerebrovascular events with a morning peak observed in humans." @default.
• W2018269715 created "2016-06-24" @default.
• W2018269715 creator A5014868745 @default.
• W2018269715 creator A5050478407 @default.
• W2018269715 creator A5063579369 @default.
• W2018269715 creator A5076645992 @default.
• W2018269715 creator A5091205019 @default.
• W2018269715 date "2005-08-01" @default.
• W2018269715 modified "2023-09-27" @default.
• W2018269715 title "Circadian periodicity in cerebral blood flow: Studies in normotensive and transgenic hypertensive rats" @default.
• W2018269715 doi "https://doi.org/10.1038/sj.jcbfm.9591524.0185" @default.
• W2018269715 hasPublicationYear "2005" @default.
• W2018269715 type Work @default.
• W2018269715 sameAs 2018269715 @default.
• W2018269715 citedByCount "0" @default.
• W2018269715 crossrefType "journal-article" @default.
• W2018269715 hasAuthorship W2018269715A5014868745 @default.
• W2018269715 hasAuthorship W2018269715A5050478407 @default.
• W2018269715 hasAuthorship W2018269715A5063579369 @default.
• W2018269715 hasAuthorship W2018269715A5076645992 @default.
• W2018269715 hasAuthorship W2018269715A5091205019 @default.
• W2018269715 hasConcept C121446783 @default.
• W2018269715 hasConcept C126322002 @default.
• W2018269715 hasConcept C134018914 @default.
• W2018269715 hasConcept C146957229 @default.
• W2018269715 hasConcept C157767197 @default.
• W2018269715 hasConcept C158846371 @default.
• W2018269715 hasConcept C164705383 @default.
• W2018269715 hasConcept C178853913 @default.
• W2018269715 hasConcept C2777953023 @default.
• W2018269715 hasConcept C57900726 @default.
• W2018269715 hasConcept C71924100 @default.
• W2018269715 hasConcept C84393581 @default.
• W2018269715 hasConcept C86803240 @default.
• W2018269715 hasConceptScore W2018269715C121446783 @default.
• W2018269715 hasConceptScore W2018269715C126322002 @default.
• W2018269715 hasConceptScore W2018269715C134018914 @default.
• W2018269715 hasConceptScore W2018269715C146957229 @default.
• W2018269715 hasConceptScore W2018269715C157767197 @default.
• W2018269715 hasConceptScore W2018269715C158846371 @default.
• W2018269715 hasConceptScore W2018269715C164705383 @default.
• W2018269715 hasConceptScore W2018269715C178853913 @default.
• W2018269715 hasConceptScore W2018269715C2777953023 @default.
• W2018269715 hasConceptScore W2018269715C57900726 @default.
• W2018269715 hasConceptScore W2018269715C71924100 @default.
• W2018269715 hasConceptScore W2018269715C84393581 @default.
• W2018269715 hasConceptScore W2018269715C86803240 @default.
• W2018269715 hasIssue "1_suppl" @default.
• W2018269715 hasLocation W20182697151 @default.
• W2018269715 hasOpenAccess W2018269715 @default.
• W2018269715 hasPrimaryLocation W20182697151 @default.
• W2018269715 hasRelatedWork W1972296525 @default.
• W2018269715 hasRelatedWork W1983217032 @default.
• W2018269715 hasRelatedWork W1986673839 @default.
• W2018269715 hasRelatedWork W2009803025 @default.
• W2018269715 hasRelatedWork W2064546786 @default.
• W2018269715 hasRelatedWork W2092341993 @default.
• W2018269715 hasRelatedWork W2093538831 @default.
• W2018269715 hasRelatedWork W2101550646 @default.
• W2018269715 hasRelatedWork W2117909172 @default.
• W2018269715 hasRelatedWork W248847570 @default.
• W2018269715 hasVolume "25" @default.
• W2018269715 isParatext "false" @default.
• W2018269715 isRetracted "false" @default.
• W2018269715 magId "2018269715" @default.
• W2018269715 workType "article" @default.