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- W2018273103 abstract "Currently, a high carbohydrate/low fat diet is recommended to prevent cardiovascular disease; however the effect of dietary fat and carbohydrate on the left ventricular (LV) adaptation to pressure overload is still unclear. Male Wistar rats were fed standard chow (SC, 52% cal from cornstarch), high sugar (HS, 60% cal from sucrose) or high fat (HF, 60% from fat). After 1 week on the diet rats underwent abdominal aorta banding (AB) or sham surgery (n=9–11/group). LV function was assessed by echocardiography before surgery and after 8 weeks. Insulin was measured by ELISA. There were no differences in these parameters between the groups prior to surgery and body weight was not different among group throughout study. As show in the table, AB caused significant increase in LV mass and LV end systolic volume (sV) in both standard and high sucrose chows. High fat decrease plasma insulin levels and prevented AB induced effects on LV function and blunted the increase in LV mass. In conclusion, high fat feeding prevented pressure overload induced cardiac LV remodeling. We speculated that the mechanism for this effect may be reduced insulin stimulated cardiac growth with the low sugar diets." @default.
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- W2018273103 date "2007-06-01" @default.
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- W2018273103 title "A high fat diet decreases plasma insulin and prevents pressure overload induced cardiac dysfunction and hypertrophy" @default.
- W2018273103 doi "https://doi.org/10.1016/j.yjmcc.2007.03.787" @default.
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