Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018276955> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2018276955 endingPage "163" @default.
- W2018276955 startingPage "153" @default.
- W2018276955 abstract "Poly(malic acid) is of interest for application as a bioresorbable carrier of polymeric drugs, which can be modified chemically. In order to provide the biodegradable macromolecular prodrug of 5-fluorouracil (5FU) reducing the side effects of 5FU, having targetability into tumor cells and exhibiting effective antitumor activity, 5FU residues and some kinds of saccharide residues were attached to poly(α-malic acid) to give poly (α-malic acid)-5FU-saccharide conjugates. Galactosamine, glucosamine, N-acetyl-d-glucosamine, mannose and mannosamine were used as saccharide residues. The antitumor activities of the obtained conjugates were tested against p388 leukemia in mice by intraperitoneal (i.p.) transplantation/ i.p. injection. The obtained poly(α-malic acid)-5FU-saccharide conjugates showed significant survival effects against p388 leukemia mice and did not display an acute toxicity in the dose range 200–800 mg/kg. The survival effects tended to increase with an increase with the degree of substitution of 5FU on the polymer based on the number of carboxylic acid groups (D5FU). The effect of saccharide units on the growth inhibition of hepatoma cells and the other tumor cells was investigated in vitro. Poly(α-malic acid)-5FU-galactosamine conjugate tended to exhibit higher growth-inhibitory effect against hepatoma cells than the other poly(α-malic acid)-5FU-saccharide conjugates. The cell specific targeting of the conjugate to hepatoma cells was suggested to be possible by using a galactosaminyl chain." @default.
- W2018276955 created "2016-06-24" @default.
- W2018276955 creator A5011399496 @default.
- W2018276955 creator A5041577539 @default.
- W2018276955 creator A5069583462 @default.
- W2018276955 date "1991-11-01" @default.
- W2018276955 modified "2023-09-23" @default.
- W2018276955 title "Design of poly(α-malic acid) -5fu-saccharide conjugate exhibiting antitumor activity" @default.
- W2018276955 cites W1968968013 @default.
- W2018276955 cites W2016710605 @default.
- W2018276955 cites W2018243960 @default.
- W2018276955 cites W2051148754 @default.
- W2018276955 cites W2069177089 @default.
- W2018276955 cites W2075267760 @default.
- W2018276955 cites W2089127403 @default.
- W2018276955 cites W2114918609 @default.
- W2018276955 cites W2304606631 @default.
- W2018276955 cites W2312974484 @default.
- W2018276955 cites W2316407198 @default.
- W2018276955 cites W4231226563 @default.
- W2018276955 cites W4233826387 @default.
- W2018276955 doi "https://doi.org/10.1016/0923-1137(91)90159-l" @default.
- W2018276955 hasPublicationYear "1991" @default.
- W2018276955 type Work @default.
- W2018276955 sameAs 2018276955 @default.
- W2018276955 citedByCount "22" @default.
- W2018276955 countsByYear W20182769552013 @default.
- W2018276955 countsByYear W20182769552014 @default.
- W2018276955 countsByYear W20182769552022 @default.
- W2018276955 crossrefType "journal-article" @default.
- W2018276955 hasAuthorship W2018276955A5011399496 @default.
- W2018276955 hasAuthorship W2018276955A5041577539 @default.
- W2018276955 hasAuthorship W2018276955A5069583462 @default.
- W2018276955 hasConcept C100817775 @default.
- W2018276955 hasConcept C108215921 @default.
- W2018276955 hasConcept C109316439 @default.
- W2018276955 hasConcept C134306372 @default.
- W2018276955 hasConcept C185592680 @default.
- W2018276955 hasConcept C197336794 @default.
- W2018276955 hasConcept C202751555 @default.
- W2018276955 hasConcept C2776648616 @default.
- W2018276955 hasConcept C2778125326 @default.
- W2018276955 hasConcept C2779032678 @default.
- W2018276955 hasConcept C2780968799 @default.
- W2018276955 hasConcept C2781467277 @default.
- W2018276955 hasConcept C33923547 @default.
- W2018276955 hasConcept C55493867 @default.
- W2018276955 hasConcept C71240020 @default.
- W2018276955 hasConceptScore W2018276955C100817775 @default.
- W2018276955 hasConceptScore W2018276955C108215921 @default.
- W2018276955 hasConceptScore W2018276955C109316439 @default.
- W2018276955 hasConceptScore W2018276955C134306372 @default.
- W2018276955 hasConceptScore W2018276955C185592680 @default.
- W2018276955 hasConceptScore W2018276955C197336794 @default.
- W2018276955 hasConceptScore W2018276955C202751555 @default.
- W2018276955 hasConceptScore W2018276955C2776648616 @default.
- W2018276955 hasConceptScore W2018276955C2778125326 @default.
- W2018276955 hasConceptScore W2018276955C2779032678 @default.
- W2018276955 hasConceptScore W2018276955C2780968799 @default.
- W2018276955 hasConceptScore W2018276955C2781467277 @default.
- W2018276955 hasConceptScore W2018276955C33923547 @default.
- W2018276955 hasConceptScore W2018276955C55493867 @default.
- W2018276955 hasConceptScore W2018276955C71240020 @default.
- W2018276955 hasLocation W20182769551 @default.
- W2018276955 hasOpenAccess W2018276955 @default.
- W2018276955 hasPrimaryLocation W20182769551 @default.
- W2018276955 hasRelatedWork W1963651555 @default.
- W2018276955 hasRelatedWork W2017305433 @default.
- W2018276955 hasRelatedWork W2018276955 @default.
- W2018276955 hasRelatedWork W2038877135 @default.
- W2018276955 hasRelatedWork W2039360218 @default.
- W2018276955 hasRelatedWork W2048713663 @default.
- W2018276955 hasRelatedWork W2060349998 @default.
- W2018276955 hasRelatedWork W2321395079 @default.
- W2018276955 hasRelatedWork W2381142496 @default.
- W2018276955 hasRelatedWork W2790799279 @default.
- W2018276955 hasVolume "15" @default.
- W2018276955 isParatext "false" @default.
- W2018276955 isRetracted "false" @default.
- W2018276955 magId "2018276955" @default.
- W2018276955 workType "article" @default.