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- W2018280069 abstract "The non-erythroid porphobilinogen deaminase (E.C. 4.3.1.8) promoter was investigated according to sequence changes and transcriptional activity. The minimal promoter sequence required for maximal transcription, was localized by deletion mapping to -243 to -115 relative to the translational start site. A negative transcriptional element was found between -55 and +1, indicating a repression mechanism. A new polymorphism was identified, at position -235 within the minimal promoter, both in acute intermittent porphyria patients and healthy control subjects. The polymorphic variants did not affect expression of cloned promoter fragments under the conditions used." @default.
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- W2018280069 title "Characterization and Regulation of the Nonerythroid Porphobilinogen Deaminase Promoter" @default.
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- W2018280069 doi "https://doi.org/10.1006/bbrc.1997.6114" @default.
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