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- W2018284921 abstract "Structure−activity relationship studies centered around 3‘-substituted (Z)-5-(2‘-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume." @default.
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- W2018284921 date "2007-08-17" @default.
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- W2018284921 title "Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma" @default.
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- W2018284921 doi "https://doi.org/10.1021/jm070370z" @default.
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