Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018285835> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2018285835 endingPage "1799" @default.
- W2018285835 startingPage "1797" @default.
- W2018285835 abstract "Background Muscle atrophy impacts almost every patient seen for orthopaedic conditions. Unfortunately, no effective treatment is available to date. Matrix metalloproteinases (MMPs), especially MMP-2, are involved in skeletal muscle atrophy. MMP-2 null mice reportedly have substantially reduced muscle atrophy after tendon transection compared with wild-type mice, suggesting MMP-2 plays an important role in muscle atrophy. Although the exact mechanisms remain unknown, a newly-discovered intracellular form of MMP-2 suggests a possible novel mechanism of MMP-2 digesting muscle matrix during muscle atrophy. I propose a new pharmacologic treatment for muscle atrophy using selective MMP-2 inhibitors. Questions/Hypothesis I hypothesize: (1) intracellular MMP-2 plays an important role during muscle atrophy by digesting intramuscular matrix; (2) AP-1 and NFAT signal transduction pathways are responsible for expression and activation of the intracellular MMP-2 during muscle atrophy; and (3) specific MMP-2 inhibitors can serve as a novel pharmacologic strategy in treating disuse-induced muscle atrophy. Method of Study Expression and activity of extracellular and intracellular MMP-2 will be determined in a mouse tendon transection model. The role of AP-1 and NFAT signal transduction pathways in MMP-2 transcriptional regulation in muscle atrophy will be determined using chromatin-immunoprecipitation (ChIP) and small interfering RNA (siRNA). I also will test the feasibility of treating muscle atrophy using selective MMP-2 inhibitors. Significance Understanding the signaling transduction pathway of extracellular and intracellular MMP-2 expression during muscle atrophy may lead to novel treatments for muscle atrophy that preserve the normal physiologic function of MMP-2." @default.
- W2018285835 created "2016-06-24" @default.
- W2018285835 creator A5032973972 @default.
- W2018285835 date "2011-06-01" @default.
- W2018285835 modified "2023-09-27" @default.
- W2018285835 title "Emerging Ideas: Matrix Metalloproteinase-2 in Muscle Atrophy" @default.
- W2018285835 cites W2103200796 @default.
- W2018285835 cites W317988326 @default.
- W2018285835 doi "https://doi.org/10.1007/s11999-010-1726-5" @default.
- W2018285835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3094615" @default.
- W2018285835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21132408" @default.
- W2018285835 hasPublicationYear "2011" @default.
- W2018285835 type Work @default.
- W2018285835 sameAs 2018285835 @default.
- W2018285835 citedByCount "5" @default.
- W2018285835 countsByYear W20182858352012 @default.
- W2018285835 countsByYear W20182858352013 @default.
- W2018285835 countsByYear W20182858352017 @default.
- W2018285835 countsByYear W20182858352021 @default.
- W2018285835 crossrefType "journal-article" @default.
- W2018285835 hasAuthorship W2018285835A5032973972 @default.
- W2018285835 hasBestOaLocation W20182858351 @default.
- W2018285835 hasConcept C109523444 @default.
- W2018285835 hasConcept C126322002 @default.
- W2018285835 hasConcept C128057223 @default.
- W2018285835 hasConcept C134018914 @default.
- W2018285835 hasConcept C142724271 @default.
- W2018285835 hasConcept C189165786 @default.
- W2018285835 hasConcept C189938988 @default.
- W2018285835 hasConcept C2776263037 @default.
- W2018285835 hasConcept C2781172350 @default.
- W2018285835 hasConcept C2911091166 @default.
- W2018285835 hasConcept C62478195 @default.
- W2018285835 hasConcept C71924100 @default.
- W2018285835 hasConcept C79879829 @default.
- W2018285835 hasConcept C86803240 @default.
- W2018285835 hasConcept C95444343 @default.
- W2018285835 hasConceptScore W2018285835C109523444 @default.
- W2018285835 hasConceptScore W2018285835C126322002 @default.
- W2018285835 hasConceptScore W2018285835C128057223 @default.
- W2018285835 hasConceptScore W2018285835C134018914 @default.
- W2018285835 hasConceptScore W2018285835C142724271 @default.
- W2018285835 hasConceptScore W2018285835C189165786 @default.
- W2018285835 hasConceptScore W2018285835C189938988 @default.
- W2018285835 hasConceptScore W2018285835C2776263037 @default.
- W2018285835 hasConceptScore W2018285835C2781172350 @default.
- W2018285835 hasConceptScore W2018285835C2911091166 @default.
- W2018285835 hasConceptScore W2018285835C62478195 @default.
- W2018285835 hasConceptScore W2018285835C71924100 @default.
- W2018285835 hasConceptScore W2018285835C79879829 @default.
- W2018285835 hasConceptScore W2018285835C86803240 @default.
- W2018285835 hasConceptScore W2018285835C95444343 @default.
- W2018285835 hasIssue "6" @default.
- W2018285835 hasLocation W20182858351 @default.
- W2018285835 hasLocation W20182858352 @default.
- W2018285835 hasLocation W20182858353 @default.
- W2018285835 hasLocation W20182858354 @default.
- W2018285835 hasOpenAccess W2018285835 @default.
- W2018285835 hasPrimaryLocation W20182858351 @default.
- W2018285835 hasRelatedWork W171363484 @default.
- W2018285835 hasRelatedWork W1754220768 @default.
- W2018285835 hasRelatedWork W1970295191 @default.
- W2018285835 hasRelatedWork W1978431399 @default.
- W2018285835 hasRelatedWork W2018285835 @default.
- W2018285835 hasRelatedWork W2060936712 @default.
- W2018285835 hasRelatedWork W2091139028 @default.
- W2018285835 hasRelatedWork W2095269303 @default.
- W2018285835 hasRelatedWork W2156234950 @default.
- W2018285835 hasRelatedWork W74938519 @default.
- W2018285835 hasVolume "469" @default.
- W2018285835 isParatext "false" @default.
- W2018285835 isRetracted "false" @default.
- W2018285835 magId "2018285835" @default.
- W2018285835 workType "article" @default.