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- W2018287773 abstract "This chapter describes studies focusing on human antiparasitic agents. The binding of 8-aminoquinoline antimalarials to DNA comparable to that with chloroquine was analyzed. It was suggested that the effect on DNA function may be involved with antimalarial activity. Co-enzyme Q that is associated with the mitochondrial oxidation of DPNH and succinate and is present in the metabolism of the parasite was shown to be inhibited by chloroquine, primaquine, quinacrine, and menoctone, thus suggesting diversity of action for antimalarial drugs. Metachloridine was shown to be active in rodent malaria. It was less active than some of the newer sulfonamides, but was considerably less toxic. The phenazine derivative, 2-(4-chlorophenyl)-3-isopropylimino-5-(4-chlorophenyl)-3,5-dihydrophenazine, which was shown to have antileprosy activity in man, was found to be active against Plasmodium berghei. In another study, the antiamebic properties of metronidazole both in intestinal and hepatic infections were demonstrated. The results suggested that a high concentration of the drug is more important than duration of treatment. Doses of 1.2–2.4 g per day for five days were effective. Teclozan, a bis(dichoroacetamido) compound used for intestinal amebiasis, was investigated in a mental hospital as a prophylactic agent. In a six-month study, a weekly dose of 200–300 mg resulted in a reduced reinfection rate compared to a control group of untreated patients." @default.
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- W2018287773 date "1969-01-01" @default.
- W2018287773 modified "2023-09-25" @default.
- W2018287773 title "Chapter 12. Human Antiparasitic Agents" @default.
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- W2018287773 doi "https://doi.org/10.1016/s0065-7743(08)60652-1" @default.
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