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• W2018289634 abstract "The Dlk1 (delta-like-1) gene is a member of the epidermal growth factor (EGF)-like homeotic gene family. It influences cell–cell interactions between stromal cells and pro-B cells in vitro. To define the in vivo role of the dlk protein in B cell development, we established a Dlk1−/− mouse model. In spleens of Dlk1−/− mice, transitional B cell numbers were increased and the ratio between transitional B cell subsets was altered. Numbers of follicular B cells decreased, while the number of marginal zone B cells and the size of the marginal zone were increased. Loss of dlk resulted in increased immunoglobulin G1 (IgG1) and IgG3 in preimmune sera. Furthermore, there was an exaggerated primary T-dependent antigen-specific humoral immune response. In bone marrow, the lack of dlk led to increased numbers of the earliest B lineage cells in young mice without affecting numbers of later B lineage cells. In vitro experiments showed that lack of dlk on either stromal cells or pro-B cells caused changes in differentiation and proliferation of pro-B cells, suggesting that lack of dlk leads to changes in cell–cell interactions in the bone marrow microenvironment. These results show that dlk expression is essential for normal B cell development." @default.
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• W2018289634 date "2008-06-01" @default.
• W2018289634 modified "2023-09-30" @default.
• W2018289634 title "<i>Dlk1</i>Influences Differentiation and Function of<i>β</i>Lymphocytes" @default.
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• W2018289634 doi "https://doi.org/10.1089/scd.2007.0102" @default.
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