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- W2018290239 abstract "The ability of a series of tetrahydroisoquinoline (THIQ) alkaloids to inhibit the binding of radioligands to catecholamine receptors in the CNS has been examined. (+) THP was the most potent inhibitor of [3H] dihydroalprenolol binding to β-adrenergic receptors and of [3H] haloperidol to dopaminergic receptors and was the least potent inhibitor of [3H] WB-4101 binding to α-adrenergic receptors. Other THIQ alkaloids examined such as salsoline, salsolinol, and reticuline were less potent than (+) THP in inhibiting radioligand binding to β-adrenergic and dopaminergic receptors, and more potent than (+) THP in inhibiting radioligand to α-adrenergic receptors. The marked potency of (+) THP in inhibiting radioligand binding to β-adrenergic receptors (IC50 ∼ 10−7 M) was confirmed by the potency of this compound in inhibiting (−) isoproternol elicited accumulations of cyclic AMP in brain slice preparations. These data indicate that, if formed in vivo during alcohol consumption, THIQ derivatives such as THP may affect catecholamine neurons in the CNS." @default.
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- W2018290239 title "Catecholamine receptors and cyclic and formation in the central nervous system: Effects of tetrahydroisoquinoline derivatives" @default.
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- W2018290239 doi "https://doi.org/10.1016/0024-3205(78)90023-1" @default.
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