Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018293456> ?p ?o ?g. }
- W2018293456 endingPage "108" @default.
- W2018293456 startingPage "101" @default.
- W2018293456 abstract "Activity-dependent neurotrophic factor (ADNF) is produced by astrocytes in response to neuronal depolarization and, in turn, promotes neuronal survival. A nineamino acid ADNF peptide (ADNF9) exhibits full neurotrophic activity and potently protects cultured embryonic rat hippocampal neurons from oxidative injury and apoptosis. Picomolar concentrations of ADNF9 induced an increase in nuclear factor-kappaB (NF-kappaB) DNA-binding activity within 1 h of exposure, with a maximum increase of approximately 10-fold by 6 h. Activation of NF-kappaB was correlated with increased resistance of neurons to apoptosis induced by exposure to Fe(2+). The antiapoptotic action of ADNF9 was abolished when NF-kappaB activation was specifically blocked with kappaB decoy DNA. Oxidative stress was attenuated in neurons pretreated with ADNF9, and this effect of ADNF9 was blocked by kappaB decoy DNA, suggesting that ADNF9 suppresses apoptosis by reducing oxidative stress. ADNF9 also prevented neuronal apoptosis following trophic factor withdrawal via an NF-kappaB-mediated mechanism. Thus, NF-kappaB mediates the neuron survival-promoting effects of ADNF9 in experimental models relevant to developmental neuronal death and neurodegenerative disorders." @default.
- W2018293456 created "2016-06-24" @default.
- W2018293456 creator A5037901121 @default.
- W2018293456 creator A5070380689 @default.
- W2018293456 creator A5083040475 @default.
- W2018293456 date "2001-12-25" @default.
- W2018293456 modified "2023-10-13" @default.
- W2018293456 title "Nuclear Factor-κB Mediates the Cell Survival-Promoting Action of Activity-Dependent Neurotrophic Factor Peptide-9" @default.
- W2018293456 cites W1507112934 @default.
- W2018293456 cites W1507242444 @default.
- W2018293456 cites W1534895763 @default.
- W2018293456 cites W1537390295 @default.
- W2018293456 cites W1605005350 @default.
- W2018293456 cites W1754199354 @default.
- W2018293456 cites W1806022925 @default.
- W2018293456 cites W1830456158 @default.
- W2018293456 cites W1900066504 @default.
- W2018293456 cites W1965168699 @default.
- W2018293456 cites W1978387914 @default.
- W2018293456 cites W1978874104 @default.
- W2018293456 cites W1979302187 @default.
- W2018293456 cites W1981513372 @default.
- W2018293456 cites W1982784171 @default.
- W2018293456 cites W1990983206 @default.
- W2018293456 cites W1995505431 @default.
- W2018293456 cites W1996901446 @default.
- W2018293456 cites W1997354645 @default.
- W2018293456 cites W2002507218 @default.
- W2018293456 cites W2003266651 @default.
- W2018293456 cites W2012300064 @default.
- W2018293456 cites W2013906894 @default.
- W2018293456 cites W2014761527 @default.
- W2018293456 cites W2016074466 @default.
- W2018293456 cites W2019683276 @default.
- W2018293456 cites W2024476573 @default.
- W2018293456 cites W2033775249 @default.
- W2018293456 cites W2037024392 @default.
- W2018293456 cites W2054021444 @default.
- W2018293456 cites W2054695619 @default.
- W2018293456 cites W2068428998 @default.
- W2018293456 cites W2081555648 @default.
- W2018293456 cites W2090006465 @default.
- W2018293456 cites W2093950048 @default.
- W2018293456 cites W2117104323 @default.
- W2018293456 cites W2136002830 @default.
- W2018293456 cites W2140660632 @default.
- W2018293456 cites W2144232114 @default.
- W2018293456 cites W2153690605 @default.
- W2018293456 cites W2155747798 @default.
- W2018293456 cites W2166781237 @default.
- W2018293456 cites W2169079203 @default.
- W2018293456 cites W2333111614 @default.
- W2018293456 cites W4322703208 @default.
- W2018293456 cites W43967522 @default.
- W2018293456 doi "https://doi.org/10.1046/j.1471-4159.2000.0750101.x" @default.
- W2018293456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10854252" @default.
- W2018293456 hasPublicationYear "2001" @default.
- W2018293456 type Work @default.
- W2018293456 sameAs 2018293456 @default.
- W2018293456 citedByCount "79" @default.
- W2018293456 countsByYear W20182934562012 @default.
- W2018293456 countsByYear W20182934562013 @default.
- W2018293456 countsByYear W20182934562014 @default.
- W2018293456 countsByYear W20182934562017 @default.
- W2018293456 countsByYear W20182934562019 @default.
- W2018293456 countsByYear W20182934562020 @default.
- W2018293456 countsByYear W20182934562023 @default.
- W2018293456 crossrefType "journal-article" @default.
- W2018293456 hasAuthorship W2018293456A5037901121 @default.
- W2018293456 hasAuthorship W2018293456A5070380689 @default.
- W2018293456 hasAuthorship W2018293456A5083040475 @default.
- W2018293456 hasBestOaLocation W20182934561 @default.
- W2018293456 hasConcept C134018914 @default.
- W2018293456 hasConcept C143425029 @default.
- W2018293456 hasConcept C160539049 @default.
- W2018293456 hasConcept C169760540 @default.
- W2018293456 hasConcept C170493617 @default.
- W2018293456 hasConcept C185592680 @default.
- W2018293456 hasConcept C190283241 @default.
- W2018293456 hasConcept C2776151105 @default.
- W2018293456 hasConcept C2778794669 @default.
- W2018293456 hasConcept C2779179475 @default.
- W2018293456 hasConcept C31573885 @default.
- W2018293456 hasConcept C552990157 @default.
- W2018293456 hasConcept C55493867 @default.
- W2018293456 hasConcept C86803240 @default.
- W2018293456 hasConcept C92020748 @default.
- W2018293456 hasConcept C95444343 @default.
- W2018293456 hasConceptScore W2018293456C134018914 @default.
- W2018293456 hasConceptScore W2018293456C143425029 @default.
- W2018293456 hasConceptScore W2018293456C160539049 @default.
- W2018293456 hasConceptScore W2018293456C169760540 @default.
- W2018293456 hasConceptScore W2018293456C170493617 @default.
- W2018293456 hasConceptScore W2018293456C185592680 @default.
- W2018293456 hasConceptScore W2018293456C190283241 @default.
- W2018293456 hasConceptScore W2018293456C2776151105 @default.
- W2018293456 hasConceptScore W2018293456C2778794669 @default.
- W2018293456 hasConceptScore W2018293456C2779179475 @default.