FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018294583> ?p ?o ?g. }

• W2018294583 endingPage "824" @default.
• W2018294583 startingPage "815" @default.
• W2018294583 abstract "Low-efficacy mu opioid receptor agonists may be useful for some clinical indications, but clinically available low-efficacy mu agonists also have low selectivity for mu vs. kappa opioid receptors. NAQ (17-cyclopropylmethyl-3,14ß-dihydroxy-4,5α-epoxy-6α-[(3′-isoquinolyl)acetamido]morphinan) is a novel opioid receptor ligand with low-efficacy at mu receptors and greater mu-receptor selectivity than existing low-efficacy agonists. This study examined behavioral effects of NAQ in rats using an intracranial self-stimulation (ICSS) procedure that has been used previously to examine other opioids. NAQ effects were examined before, during, and after chronic morphine treatment, and effects of NAQ were compared to effects of nalbuphine and naltrexone. Adult male Sprague–Dawley rats were trained to respond for electrical brain stimulation delivered via electrodes implanted in the medial forebrain bundle. A range of brain stimulation frequencies maintained a wide range of baseline ICSS rates. Effects of NAQ (0.32–10 mg/kg), nalbuphine (1.0 mg/kg), and naltrexone (0.1 mg/kg) were determined before morphine treatment and during treatment with 3.2 and 18 mg/kg/day morphine. NAQ effects were also redetermined beginning 2 weeks after termination of morphine treatment. NAQ produced weak ICSS facilitation in morphine-naïve rats but more robust ICSS facilitation during and after morphine treatment and also reversed morphine withdrawal-associated depression of ICSS. These effects were similar to effects of nalbuphine. These results agree with the in vitro characterization of NAQ as a low-efficacy mu agonist. Opioid exposure may enhance abuse-related effects of NAQ, but NAQ may also serve as a low-efficacy and relatively safe option for treatment of opioid withdrawal or dependence." @default.
• W2018294583 created "2016-06-24" @default.
• W2018294583 creator A5010098064 @default.
• W2018294583 creator A5011138377 @default.
• W2018294583 creator A5020814543 @default.
• W2018294583 creator A5026944150 @default.
• W2018294583 creator A5086664284 @default.
• W2018294583 date "2014-09-03" @default.
• W2018294583 modified "2023-10-16" @default.
• W2018294583 title "Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats" @default.
• W2018294583 cites W1972095807 @default.
• W2018294583 cites W1973040201 @default.
• W2018294583 cites W1980915383 @default.
• W2018294583 cites W1988659186 @default.
• W2018294583 cites W1998777715 @default.
• W2018294583 cites W2006955424 @default.
• W2018294583 cites W2008279171 @default.
• W2018294583 cites W2008939320 @default.
• W2018294583 cites W2013984180 @default.
• W2018294583 cites W2018184496 @default.
• W2018294583 cites W2027368945 @default.
• W2018294583 cites W2032643119 @default.
• W2018294583 cites W2038120147 @default.
• W2018294583 cites W2038357611 @default.
• W2018294583 cites W2049534380 @default.
• W2018294583 cites W2068919679 @default.
• W2018294583 cites W2071379530 @default.
• W2018294583 cites W2073890140 @default.
• W2018294583 cites W2076687314 @default.
• W2018294583 cites W2089274770 @default.
• W2018294583 cites W2106210170 @default.
• W2018294583 cites W2111774737 @default.
• W2018294583 cites W2118087188 @default.
• W2018294583 cites W2122150204 @default.
• W2018294583 cites W2134431067 @default.
• W2018294583 cites W2141611982 @default.
• W2018294583 cites W2148208755 @default.
• W2018294583 cites W2166772620 @default.
• W2018294583 cites W2485023302 @default.
• W2018294583 cites W2495485429 @default.
• W2018294583 cites W2496610147 @default.
• W2018294583 doi "https://doi.org/10.1007/s00213-014-3719-7" @default.
• W2018294583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4310756" @default.
• W2018294583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25178814" @default.
• W2018294583 hasPublicationYear "2014" @default.
• W2018294583 type Work @default.
• W2018294583 sameAs 2018294583 @default.
• W2018294583 citedByCount "15" @default.
• W2018294583 countsByYear W20182945832015 @default.
• W2018294583 countsByYear W20182945832016 @default.
• W2018294583 countsByYear W20182945832017 @default.
• W2018294583 countsByYear W20182945832018 @default.
• W2018294583 countsByYear W20182945832019 @default.
• W2018294583 countsByYear W20182945832020 @default.
• W2018294583 countsByYear W20182945832021 @default.
• W2018294583 countsByYear W20182945832022 @default.
• W2018294583 countsByYear W20182945832023 @default.
• W2018294583 crossrefType "journal-article" @default.
• W2018294583 hasAuthorship W2018294583A5010098064 @default.
• W2018294583 hasAuthorship W2018294583A5011138377 @default.
• W2018294583 hasAuthorship W2018294583A5020814543 @default.
• W2018294583 hasAuthorship W2018294583A5026944150 @default.
• W2018294583 hasAuthorship W2018294583A5086664284 @default.
• W2018294583 hasBestOaLocation W20182945832 @default.
• W2018294583 hasConcept C126322002 @default.
• W2018294583 hasConcept C170493617 @default.
• W2018294583 hasConcept C185592680 @default.
• W2018294583 hasConcept C24998067 @default.
• W2018294583 hasConcept C2776669363 @default.
• W2018294583 hasConcept C2777389121 @default.
• W2018294583 hasConcept C2777972943 @default.
• W2018294583 hasConcept C2778938600 @default.
• W2018294583 hasConcept C2778977083 @default.
• W2018294583 hasConcept C2779886867 @default.
• W2018294583 hasConcept C2780062018 @default.
• W2018294583 hasConcept C2781063702 @default.
• W2018294583 hasConcept C42219234 @default.
• W2018294583 hasConcept C513476851 @default.
• W2018294583 hasConcept C71924100 @default.
• W2018294583 hasConcept C98274493 @default.
• W2018294583 hasConceptScore W2018294583C126322002 @default.
• W2018294583 hasConceptScore W2018294583C170493617 @default.
• W2018294583 hasConceptScore W2018294583C185592680 @default.
• W2018294583 hasConceptScore W2018294583C24998067 @default.
• W2018294583 hasConceptScore W2018294583C2776669363 @default.
• W2018294583 hasConceptScore W2018294583C2777389121 @default.
• W2018294583 hasConceptScore W2018294583C2777972943 @default.
• W2018294583 hasConceptScore W2018294583C2778938600 @default.
• W2018294583 hasConceptScore W2018294583C2778977083 @default.
• W2018294583 hasConceptScore W2018294583C2779886867 @default.
• W2018294583 hasConceptScore W2018294583C2780062018 @default.
• W2018294583 hasConceptScore W2018294583C2781063702 @default.
• W2018294583 hasConceptScore W2018294583C42219234 @default.
• W2018294583 hasConceptScore W2018294583C513476851 @default.
• W2018294583 hasConceptScore W2018294583C71924100 @default.
• W2018294583 hasConceptScore W2018294583C98274493 @default.
• W2018294583 hasIssue "4" @default.
• W2018294583 hasLocation W20182945831 @default.

• next