FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018296440> ?p ?o ?g. }

• W2018296440 endingPage "116" @default.
• W2018296440 startingPage "107" @default.
• W2018296440 abstract "Development of the various components of a normal skeleton requires highly regulated signalling systems that co-ordinate spatial and temporal patterns of cell division, cell differentiation, and morphogenesis. Much work in recent decades has revealed cascades of molecular signalling, acting through key transcription factors to regulate, for example, organized chondrogenic and osteogenic differentiation. It is now clear that mechanical stimuli are also required for aspects of skeletogenesis but very little is known about how the mechanical signals are integrated with classic biochemical signalling. Spatially organized differentiation is vital to the production of functionally appropriate tissues contributing to precise, region specific morphologies, for example transient chondrogenesis of long bone skeletal rudiments, which prefigures osteogenic replacement of the cartilage template, compared with the production of permanent cartilage at the sites of articulation. Currently a lack of understanding of how these tissues are differentially regulated hampers efforts to specifically regenerate stable bone and cartilage. Here, we review current research revealing the influence of mechanical stimuli on specific aspects of skeletal development and refer to other developing systems to set the scene for current and future work to uncover the molecular mechanisms involved. We integrate this with a brief overview of the effects of mechanical stimulation on stem cells in culture bringing together developmental and tissue engineering aspects of mechanoregulation of cell behavior. A better understanding of the molecular mechanisms that link mechanical stimuli to transcriptional control guiding cell differentiation will lead to new ideas about how to effectively prime stem cells for tissue engineering and regenerative therapies." @default.
• W2018296440 created "2016-06-24" @default.
• W2018296440 creator A5015673217 @default.
• W2018296440 creator A5020208763 @default.
• W2018296440 creator A5051114666 @default.
• W2018296440 date "2013-03-07" @default.
• W2018296440 modified "2023-10-16" @default.
• W2018296440 title "Mechanical Regulation of Skeletal Development" @default.
• W2018296440 cites W1586169243 @default.
• W2018296440 cites W1782202106 @default.
• W2018296440 cites W1964752771 @default.
• W2018296440 cites W1968010523 @default.
• W2018296440 cites W1968649940 @default.
• W2018296440 cites W1970902059 @default.
• W2018296440 cites W1971198742 @default.
• W2018296440 cites W1977946489 @default.
• W2018296440 cites W1978772690 @default.
• W2018296440 cites W1980986010 @default.
• W2018296440 cites W1982323513 @default.
• W2018296440 cites W1984307368 @default.
• W2018296440 cites W1990292037 @default.
• W2018296440 cites W1990892261 @default.
• W2018296440 cites W1990949147 @default.
• W2018296440 cites W1993006648 @default.
• W2018296440 cites W1995527685 @default.
• W2018296440 cites W2001108592 @default.
• W2018296440 cites W2004706898 @default.
• W2018296440 cites W2006224414 @default.
• W2018296440 cites W2006594271 @default.
• W2018296440 cites W2006758883 @default.
• W2018296440 cites W2009186219 @default.
• W2018296440 cites W2011810078 @default.
• W2018296440 cites W2015748224 @default.
• W2018296440 cites W2017741123 @default.
• W2018296440 cites W2018634292 @default.
• W2018296440 cites W2020451860 @default.
• W2018296440 cites W2022362035 @default.
• W2018296440 cites W2026081091 @default.
• W2018296440 cites W2030474254 @default.
• W2018296440 cites W2032328269 @default.
• W2018296440 cites W2035340393 @default.
• W2018296440 cites W2036779499 @default.
• W2018296440 cites W2042932723 @default.
• W2018296440 cites W2045683512 @default.
• W2018296440 cites W2046212734 @default.
• W2018296440 cites W2049718632 @default.
• W2018296440 cites W2058256770 @default.
• W2018296440 cites W2065005994 @default.
• W2018296440 cites W2065587003 @default.
• W2018296440 cites W2066636044 @default.
• W2018296440 cites W2070317775 @default.
• W2018296440 cites W2074800593 @default.
• W2018296440 cites W2076074347 @default.
• W2018296440 cites W2076513735 @default.
• W2018296440 cites W2077309660 @default.
• W2018296440 cites W2079475603 @default.
• W2018296440 cites W2080592158 @default.
• W2018296440 cites W2086998851 @default.
• W2018296440 cites W2089700069 @default.
• W2018296440 cites W2090073689 @default.
• W2018296440 cites W2090778914 @default.
• W2018296440 cites W2091152589 @default.
• W2018296440 cites W2097156505 @default.
• W2018296440 cites W2097444304 @default.
• W2018296440 cites W2113335122 @default.
• W2018296440 cites W2113533023 @default.
• W2018296440 cites W2115758207 @default.
• W2018296440 cites W2117261424 @default.
• W2018296440 cites W2118550160 @default.
• W2018296440 cites W2119882428 @default.
• W2018296440 cites W2126326508 @default.
• W2018296440 cites W2127984548 @default.
• W2018296440 cites W2128853335 @default.
• W2018296440 cites W2130804510 @default.
• W2018296440 cites W2130837546 @default.
• W2018296440 cites W2135166914 @default.
• W2018296440 cites W2150004435 @default.
• W2018296440 cites W2151371698 @default.
• W2018296440 cites W2156462635 @default.
• W2018296440 cites W2156821125 @default.
• W2018296440 cites W2156859975 @default.
• W2018296440 cites W2157664121 @default.
• W2018296440 cites W2158619848 @default.
• W2018296440 cites W2160469740 @default.
• W2018296440 cites W2160679726 @default.
• W2018296440 cites W2161969451 @default.
• W2018296440 cites W2164112925 @default.
• W2018296440 cites W2166428507 @default.
• W2018296440 cites W2168164428 @default.
• W2018296440 cites W2168730320 @default.
• W2018296440 cites W38879183 @default.
• W2018296440 doi "https://doi.org/10.1007/s11914-013-0137-4" @default.
• W2018296440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23467901" @default.
• W2018296440 hasPublicationYear "2013" @default.
• W2018296440 type Work @default.
• W2018296440 sameAs 2018296440 @default.
• W2018296440 citedByCount "20" @default.
• W2018296440 countsByYear W20182964402014 @default.

• next