FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018296703> ?p ?o ?g. }

• W2018296703 endingPage "13" @default.
• W2018296703 startingPage "8" @default.
• W2018296703 abstract "AVE 3085 is a novel endothelial nitric oxide synthase enhancer. Although AVE 3085 treatment has been shown to be effective in spontaneously restoring endothelial function in hypertensive rats, little is known about the effects and mechanisms of AVE 3085 with respect to cardiac remodeling. The present study was designed to examine the effects of AVE 3085 on cardiac remodeling and the mechanisms underlying the effects of this compound. Mice were subjected to aortic banding to induce cardiac remodeling and were then administered AVE 3085 (10 mg kg day−1, orally) for 4 weeks. At the end of the treatment, the aortic banding-treated mice exhibited significant elevations in cardiac remodeling, characterized by an increase in left ventricular weight relative to body weight, an increase in the area of collagen deposition, an increase in the mean myocyte diameter, and increases in the gene expressions of the hypertrophic markers atrial natriuretic peptide (ANP) and β-MHC. These indexes were significantly decreased in the AVE 3085-treated mice. Furthermore, AVE 3085 treatment reduced the expression and activation of the Smad signaling pathway in the aortic banding-treated mice. Our data showed that AVE 3085 attenuated cardiac remodeling, and this effect was possibly mediated through the inhibition of Smad signaling." @default.
• W2018296703 created "2016-06-24" @default.
• W2018296703 creator A5000972933 @default.
• W2018296703 creator A5011814332 @default.
• W2018296703 creator A5027118136 @default.
• W2018296703 creator A5053312797 @default.
• W2018296703 creator A5055550746 @default.
• W2018296703 creator A5064795764 @default.
• W2018296703 creator A5067331026 @default.
• W2018296703 creator A5068072216 @default.
• W2018296703 creator A5084781430 @default.
• W2018296703 date "2015-03-01" @default.
• W2018296703 modified "2023-10-16" @default.
• W2018296703 title "AVE 3085, a novel endothelial nitric oxide synthase enhancer, attenuates cardiac remodeling in mice through the Smad signaling pathway" @default.
• W2018296703 cites W135846028 @default.
• W2018296703 cites W1531133799 @default.
• W2018296703 cites W1590591225 @default.
• W2018296703 cites W1971892871 @default.
• W2018296703 cites W1971907143 @default.
• W2018296703 cites W1973112262 @default.
• W2018296703 cites W1975742635 @default.
• W2018296703 cites W2049043480 @default.
• W2018296703 cites W2063345890 @default.
• W2018296703 cites W2072626568 @default.
• W2018296703 cites W2072819436 @default.
• W2018296703 cites W2090391107 @default.
• W2018296703 cites W2098307040 @default.
• W2018296703 cites W2104676435 @default.
• W2018296703 cites W2105430887 @default.
• W2018296703 cites W2122168706 @default.
• W2018296703 cites W2146722839 @default.
• W2018296703 cites W2153038580 @default.
• W2018296703 cites W2164540928 @default.
• W2018296703 cites W2168112142 @default.
• W2018296703 doi "https://doi.org/10.1016/j.abb.2015.02.020" @default.
• W2018296703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25712222" @default.
• W2018296703 hasPublicationYear "2015" @default.
• W2018296703 type Work @default.
• W2018296703 sameAs 2018296703 @default.
• W2018296703 citedByCount "9" @default.
• W2018296703 countsByYear W20182967032017 @default.
• W2018296703 countsByYear W20182967032018 @default.
• W2018296703 countsByYear W20182967032019 @default.
• W2018296703 countsByYear W20182967032020 @default.
• W2018296703 countsByYear W20182967032022 @default.
• W2018296703 countsByYear W20182967032023 @default.
• W2018296703 crossrefType "journal-article" @default.
• W2018296703 hasAuthorship W2018296703A5000972933 @default.
• W2018296703 hasAuthorship W2018296703A5011814332 @default.
• W2018296703 hasAuthorship W2018296703A5027118136 @default.
• W2018296703 hasAuthorship W2018296703A5053312797 @default.
• W2018296703 hasAuthorship W2018296703A5055550746 @default.
• W2018296703 hasAuthorship W2018296703A5064795764 @default.
• W2018296703 hasAuthorship W2018296703A5067331026 @default.
• W2018296703 hasAuthorship W2018296703A5068072216 @default.
• W2018296703 hasAuthorship W2018296703A5084781430 @default.
• W2018296703 hasConcept C104317684 @default.
• W2018296703 hasConcept C111936080 @default.
• W2018296703 hasConcept C118131993 @default.
• W2018296703 hasConcept C126322002 @default.
• W2018296703 hasConcept C134018914 @default.
• W2018296703 hasConcept C150194340 @default.
• W2018296703 hasConcept C185592680 @default.
• W2018296703 hasConcept C2777622882 @default.
• W2018296703 hasConcept C2778198053 @default.
• W2018296703 hasConcept C2779537366 @default.
• W2018296703 hasConcept C2781080636 @default.
• W2018296703 hasConcept C519581460 @default.
• W2018296703 hasConcept C55493867 @default.
• W2018296703 hasConcept C71924100 @default.
• W2018296703 hasConcept C86803240 @default.
• W2018296703 hasConceptScore W2018296703C104317684 @default.
• W2018296703 hasConceptScore W2018296703C111936080 @default.
• W2018296703 hasConceptScore W2018296703C118131993 @default.
• W2018296703 hasConceptScore W2018296703C126322002 @default.
• W2018296703 hasConceptScore W2018296703C134018914 @default.
• W2018296703 hasConceptScore W2018296703C150194340 @default.
• W2018296703 hasConceptScore W2018296703C185592680 @default.
• W2018296703 hasConceptScore W2018296703C2777622882 @default.
• W2018296703 hasConceptScore W2018296703C2778198053 @default.
• W2018296703 hasConceptScore W2018296703C2779537366 @default.
• W2018296703 hasConceptScore W2018296703C2781080636 @default.
• W2018296703 hasConceptScore W2018296703C519581460 @default.
• W2018296703 hasConceptScore W2018296703C55493867 @default.
• W2018296703 hasConceptScore W2018296703C71924100 @default.
• W2018296703 hasConceptScore W2018296703C86803240 @default.
• W2018296703 hasFunder F4320321001 @default.
• W2018296703 hasLocation W20182967031 @default.
• W2018296703 hasLocation W20182967032 @default.
• W2018296703 hasOpenAccess W2018296703 @default.
• W2018296703 hasPrimaryLocation W20182967031 @default.
• W2018296703 hasRelatedWork W1487086110 @default.
• W2018296703 hasRelatedWork W1966222469 @default.
• W2018296703 hasRelatedWork W2018459525 @default.
• W2018296703 hasRelatedWork W2077418945 @default.
• W2018296703 hasRelatedWork W2377457626 @default.
• W2018296703 hasRelatedWork W2384352427 @default.
• W2018296703 hasRelatedWork W2544156601 @default.

• next