FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018301294> ?p ?o ?g. }

• W2018301294 endingPage "367" @default.
• W2018301294 startingPage "360" @default.
• W2018301294 abstract "Urothelial carcinoma of bladder is the second most common urological malignancy after prostate cancer. Recently, there has been increased interest in research of the role of free radicals and antioxidant materials in the prevention, treatment, and alleviation of therapy-related side effects of cancer. In the present study, we aimed to assess the alterations in the levels of antioxidant vitamins, activities of defense enzymes, circulating lipid peroxide, and total antioxidant activity (AOA) in patients with urothelial carcinoma of bladder and correlate these changes with the grade and severity of the disease.The study cohort consisted of 90 subjects; 50 patients with bladder UC (25, low grade; 10, high grade; 15, muscle invasive) and 40 healthy controls. Vitamins C and E, malondialdehyde (MDA), and AOA were estimated using standard protocols. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) were assayed using commercially available kits.The serum levels of vitamins C and E, whole blood levels of SOD and GPx, and serum AOA was significantly lower (P < 0.001) while serum MDA levels were significantly higher (P < 0.001) in patients than in controls, indicating presence of oxidative stress in bladder UC patients. The levels of all the biochemical parameters were correlated with the grade and severity of the disease. There were significant differences between the patients with low grade tumors and muscle invasive tumors for all parameters (P < 0.001); except AOA (P < 0.279).The observed redox imbalance in UC of bladder in correlation with the grade and stage, as a consequence of decreased levels of antioxidant vitamins, enzymes, and AOA, along with increased MDA levels in circulation, may be important factors in tumor development and growth. Our results suggest that with advancing stage of bladder UC, the levels of oxidative stress increase, while levels of antioxidant molecules decrease. These findings suggest possible use of antioxidant supplementation as prophylactic agents for prevention and treatment of bladder cancer." @default.
• W2018301294 created "2016-06-24" @default.
• W2018301294 creator A5046777060 @default.
• W2018301294 creator A5053783690 @default.
• W2018301294 creator A5069552957 @default.
• W2018301294 creator A5079907660 @default.
• W2018301294 creator A5081272316 @default.
• W2018301294 date "2010-07-01" @default.
• W2018301294 modified "2023-09-30" @default.
• W2018301294 title "Altered antioxidant status and lipid peroxidation in Indian patients with urothelial bladder carcinoma" @default.
• W2018301294 cites W1511754883 @default.
• W2018301294 cites W1575245978 @default.
• W2018301294 cites W1794856894 @default.
• W2018301294 cites W1821557140 @default.
• W2018301294 cites W1855308453 @default.
• W2018301294 cites W1904857264 @default.
• W2018301294 cites W1963712961 @default.
• W2018301294 cites W1964632509 @default.
• W2018301294 cites W1967487924 @default.
• W2018301294 cites W1972833482 @default.
• W2018301294 cites W1975303582 @default.
• W2018301294 cites W1992918484 @default.
• W2018301294 cites W2003471941 @default.
• W2018301294 cites W2011421264 @default.
• W2018301294 cites W2012227562 @default.
• W2018301294 cites W2027443731 @default.
• W2018301294 cites W2027851837 @default.
• W2018301294 cites W2028282157 @default.
• W2018301294 cites W2043744334 @default.
• W2018301294 cites W2048553024 @default.
• W2018301294 cites W2049212848 @default.
• W2018301294 cites W2059929603 @default.
• W2018301294 cites W2060049759 @default.
• W2018301294 cites W2066004242 @default.
• W2018301294 cites W2072911310 @default.
• W2018301294 cites W2090102760 @default.
• W2018301294 cites W2093524580 @default.
• W2018301294 cites W2096245406 @default.
• W2018301294 cites W2118090983 @default.
• W2018301294 cites W2123668146 @default.
• W2018301294 cites W2125329352 @default.
• W2018301294 cites W2132270233 @default.
• W2018301294 cites W2138220389 @default.
• W2018301294 cites W2144685132 @default.
• W2018301294 cites W2147670431 @default.
• W2018301294 cites W2165057232 @default.
• W2018301294 cites W2171108478 @default.
• W2018301294 cites W2394647216 @default.
• W2018301294 doi "https://doi.org/10.1016/j.urolonc.2008.12.010" @default.
• W2018301294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19171490" @default.
• W2018301294 hasPublicationYear "2010" @default.
• W2018301294 type Work @default.
• W2018301294 sameAs 2018301294 @default.
• W2018301294 citedByCount "72" @default.
• W2018301294 countsByYear W20183012942012 @default.
• W2018301294 countsByYear W20183012942013 @default.
• W2018301294 countsByYear W20183012942014 @default.
• W2018301294 countsByYear W20183012942015 @default.
• W2018301294 countsByYear W20183012942017 @default.
• W2018301294 countsByYear W20183012942018 @default.
• W2018301294 countsByYear W20183012942019 @default.
• W2018301294 countsByYear W20183012942020 @default.
• W2018301294 countsByYear W20183012942021 @default.
• W2018301294 countsByYear W20183012942022 @default.
• W2018301294 crossrefType "journal-article" @default.
• W2018301294 hasAuthorship W2018301294A5046777060 @default.
• W2018301294 hasAuthorship W2018301294A5053783690 @default.
• W2018301294 hasAuthorship W2018301294A5069552957 @default.
• W2018301294 hasAuthorship W2018301294A5079907660 @default.
• W2018301294 hasAuthorship W2018301294A5081272316 @default.
• W2018301294 hasConcept C121608353 @default.
• W2018301294 hasConcept C126322002 @default.
• W2018301294 hasConcept C126894567 @default.
• W2018301294 hasConcept C134018914 @default.
• W2018301294 hasConcept C185592680 @default.
• W2018301294 hasConcept C2775838275 @default.
• W2018301294 hasConcept C2776151105 @default.
• W2018301294 hasConcept C2778004101 @default.
• W2018301294 hasConcept C2778401633 @default.
• W2018301294 hasConcept C2778760513 @default.
• W2018301294 hasConcept C2780352672 @default.
• W2018301294 hasConcept C2780829032 @default.
• W2018301294 hasConcept C2993790521 @default.
• W2018301294 hasConcept C55493867 @default.
• W2018301294 hasConcept C71924100 @default.
• W2018301294 hasConcept C90924648 @default.
• W2018301294 hasConceptScore W2018301294C121608353 @default.
• W2018301294 hasConceptScore W2018301294C126322002 @default.
• W2018301294 hasConceptScore W2018301294C126894567 @default.
• W2018301294 hasConceptScore W2018301294C134018914 @default.
• W2018301294 hasConceptScore W2018301294C185592680 @default.
• W2018301294 hasConceptScore W2018301294C2775838275 @default.
• W2018301294 hasConceptScore W2018301294C2776151105 @default.
• W2018301294 hasConceptScore W2018301294C2778004101 @default.
• W2018301294 hasConceptScore W2018301294C2778401633 @default.
• W2018301294 hasConceptScore W2018301294C2778760513 @default.
• W2018301294 hasConceptScore W2018301294C2780352672 @default.
• W2018301294 hasConceptScore W2018301294C2780829032 @default.

• next