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• W2018303721 abstract "Basic fibroblast growth factor (bFGF) induced osteoclast formation in co-cultures of mouse spleen cells and osteoblasts. Osteoclastogenesis inhibitory factor (OCIF) and a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, abolished bFGF-induced osteoclast formation. bFGF did not affect spleen cells, but it did affect osteoblasts, to stimulate osteoclast formation. Northern blot analysis revealed that bFGF up-regulated the expression of osteoclast differentiation factor (ODF) and COX-2 and down-regulated the expression of OCIF in primary osteoblastic cells. NS-398 abolished the increase of ODF mRNA, but it had no effect on the decrease of OCIF mRNA. NS-398 suppressed the binding of 125I-labeled OCIF to osteoblastic cells treated with bFGF. Enzyme-linked immunosorbent assay showed that bFGF inhibited OCIF production by osteoblastic cells, and the inhibition was not affected by NS-398. We conclude that bFGF induces osteoclast formation by stimulating ODF production through COX-2-mediated prostaglandin synthesis and by suppressing OCIF production through a mechanism independent of prostaglandin synthesis." @default.
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• W2018303721 date "1999-11-01" @default.
• W2018303721 modified "2023-10-02" @default.
• W2018303721 title "Basic Fibroblast Growth Factor Induces Osteoclast Formation by Reciprocally Regulating the Production of Osteoclast Differentiation Factor and Osteoclastogenesis Inhibitory Factor in Mouse Osteoblastic Cells" @default.
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• W2018303721 doi "https://doi.org/10.1006/bbrc.1999.1601" @default.
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