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• W2018304860 abstract "Editorials1 April 1983Cytomegalovirus Disease: Can it be Prevented?HENRY H. BALFOUR JR., M.D.HENRY H. BALFOUR JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCytomegalovirus is a major pathogen in immunosuppressed patients (1) and newborn infants (2). Effective treatment for cytomegalovirus disease has yet to be found. A placebo-controlled study of intravenous acyclovir therapy in 16 immunocompromised patients with acquired cytomegalovirus disease suggested the efficacy of this treatment (3), but this trial must be extended and confirmed before acyclovir can be classified as an anticytomegalovirus drug. Thomas and associates (4) reported that transfer factor was associated with decreased viral shedding in three congenitally infected infants but could not confirm their preliminary observations in a doubleblind trial (5). Encouraged by finding that transfer factor injections...References1. PETERSONBALFOURFRYDFERGUSONSIMMONS PHDRR. Fever in renal transplant recipients: causes, prognostic significance and changing patterns at the University of Minnesota Hospital. Am J Med. 1981;71:345-51. CrossrefMedlineGoogle Scholar2. STAGNOPASSDWORSKYALFORD SRMC. Maternal cytomegalovirus infection and perinatal transmission. Clin Obstet Gynecol. 1982;25:563-76. CrossrefMedlineGoogle Scholar3. BALFOURBEANMITCHELLSACHSBOENEDELMAN HBCGJC. Acyclovir in immunocompromised patients with cytomegalovirus disease: a controlled trial in one institution. Am J Med. 1982;73:(1A):241-8. CrossrefMedlineGoogle Scholar4. THOMASSOOTHILLHAWKINSMARSHALL IJGW. Transfer-factor treatment in congenital cytomegalovirus infection. Lancet. 1977;2:1056-7. CrossrefMedlineGoogle Scholar5. PAGANELLISOOTHILLMARSHALLHAMBLIN RJWA. Transfer factor and cytomegalovirus viruria [Letter]. Lancet. 1981;1:273-4. CrossrefMedlineGoogle Scholar6. BRUNELLROSSMILLERKUO PALB. Prevention of varicella by zoster immune globulin. N Engl J Med. 1969;280:1191-4. CrossrefMedlineGoogle Scholar7. BALFOURGROTH HK. Zoster immune plasma prophylaxis of varicella: a follow-up report. J Pediatr. 1979;94:743-6. CrossrefMedlineGoogle Scholar8. MEYERSLESZCZYNSKIZAIA JJJ. Successful prevention of cytomegalovirus infection after marrow transplant with cytomegalovirus immune globulin. Ann Intern Med. 1983;98:442-6. LinkGoogle Scholar9. PETERSONBALFOURMARKERFRYDHOWARDSIMMONS PHSDRR. Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation. Medicine. 1980;59:283-300. CrossrefMedlineGoogle Scholar10. WINSTONPOLLARDHO DRW. Cytomegalovirus immune plasma in bone marrow transplant recipients. Ann Intern Med. 1982;97:11-8. LinkGoogle Scholar11. CHEESEMANRUBINSTEWART SRJ. Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation: effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med. 1979;300:1345-9. CrossrefMedlineGoogle Scholar12. SARALBURNSLASKINSANTOSLIETMAN RWOGP. Acyclovir prophylaxis of herpes-simplex-virus infections: a randomized, double-blind controlled trial in bone-marrow-transplant recipients. N Engl J Med. 1981;305:63-7. CrossrefMedlineGoogle Scholar13. TYMSSEAMANSNAIM AEH. The in vitro activity of acyclovir and related compounds against cytomegalovirus infections. J Antimicrob Chemother. 1981;8:65-72. CrossrefMedlineGoogle Scholar14. PLOTKINFARQUHARHORNBERGER SJE. Clinical trials of immunization with the Towne 125 strain of human cytomegalovirus. J Infect Dis. 1976;134:470-5. CrossrefMedlineGoogle Scholar15. STARRGLAZERFRIEDMANFARQUHARPLOTKIN SJHJS. Specific cellular and humoral immunity after immunization with live Towne strain cytomegalovirus vaccine. J Infect Dis. 1981;143:585-9. CrossrefMedlineGoogle Scholar16. PARKSRAPP WF. Prospects for herpesvirus vaccination—safety and efficacy considerations. Progr Med Virol. 1975;21:188-206. MedlineGoogle Scholar17. BETTS R. Cytomegalovirus vaccine in renal transplants [Editorial]. Ann Intern Med. 1979;91:780-2. LinkGoogle Scholar18. OSBORN J. Cytomegalovirus: pathogenicity, immunology, and vaccine initiatives. J Infect Dis. 1981;143:618-30. CrossrefMedlineGoogle Scholar19. GLAZERFRIEDMANGROSSMAN JHR. Live cytomegalovirus vaccination of renal transplant candidates: a preliminary trial. Ann Intern Med. 1979;91:676-83. LinkGoogle Scholar20. PLOTKINFURUKAWAZYGRAICHHUYGELEN STNC. Candidate cytomegalovirus strain for human vaccination. Infect Immun. 1975;12:521-7. CrossrefMedlineGoogle Scholar21. HUANGROCHE EJ. Cytomegalovirus DNA and adenocarcinoma of the colon: evidence for latent viral infection. Lancet. 1978;1:957-60. CrossrefMedlineGoogle Scholar22. DREWCONANTMINER WMR. Cytomegalovirus and Kaposi's sarcoma in young homosexual men. Lancet. 1982;2:125-7. CrossrefMedlineGoogle Scholar23. ZIEGLERDREWMINER JWR. Outbreak of Burkitt's—like lymphoma in homosexual men. Lancet. 1982;2:631-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevalence of cytomegalovirus infection in different patient groups of a urban university in BrazilAcyclovir in preventing cytomegalovirus infection in kidney transplant recipients: A case-controlled studyOptions for Prevention of Cytomegalovirus DiseaseHenry H. Balfour Jr., MDLong-term complications of cardiac transplantationThe Prevention of Cytomegalovirus Disease in Renal TransplantationA Multivariate Analysis of Risk Factors for Cytomegalovirus Infection in Liver-Transplant RecipientsThe interrelationship of immunosuppression and cytomegalovirus infectionInterstitial pneumonitis following bone marrow transplantation: Pathogenesis and therapeutic considerationsBone marrow transplantationTransfusion-Transmitted CMV Infections Clinical Importance and Means of Prevention?Cytomegalovirus infections in renal transplant recipients.Prophylaxe und Therapie von Cytomegalie-Infektionen nach KnochenmarktransplantationElectron microscopic examination of congenital cytomegalovirus hepatitis 1 April 1983Volume 98, Issue 4Page: 544-546KeywordsDrug therapyInfantsPathogens Issue Published: 1 April 1983 PDF downloadLoading ..." @default.
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