Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018304908> ?p ?o ?g. }
- W2018304908 endingPage "532" @default.
- W2018304908 startingPage "517" @default.
- W2018304908 abstract "Germ cell specification is accompanied by epigenetic remodeling, the scale and specificity of which are unclear. Here, we quantitatively delineate chromatin dynamics during induction of mouse embryonic stem cells (ESCs) to epiblast-like cells (EpiLCs) and from there into primordial germ cell-like cells (PGCLCs), revealing large-scale reorganization of chromatin signatures including H3K27me3 and H3K9me2 patterns. EpiLCs contain abundant bivalent gene promoters characterized by low H3K27me3, indicating a state primed for differentiation. PGCLCs initially lose H3K4me3 from many bivalent genes but subsequently regain this mark with concomitant upregulation of H3K27me3, particularly at developmental regulatory genes. PGCLCs progressively lose H3K9me2, including at lamina-associated perinuclear heterochromatin, resulting in changes in nuclear architecture. T recruits H3K27ac to activate BLIMP1 and early mesodermal programs during PGCLC specification, which is followed by BLIMP1-mediated repression of a broad range of targets, possibly through recruitment and spreading of H3K27me3. These findings provide a foundation for reconstructing regulatory networks of the germline epigenome." @default.
- W2018304908 created "2016-06-24" @default.
- W2018304908 creator A5000648036 @default.
- W2018304908 creator A5004628851 @default.
- W2018304908 creator A5011658917 @default.
- W2018304908 creator A5016484890 @default.
- W2018304908 creator A5021449949 @default.
- W2018304908 creator A5027986002 @default.
- W2018304908 creator A5034949085 @default.
- W2018304908 creator A5036805154 @default.
- W2018304908 creator A5042230160 @default.
- W2018304908 creator A5047338296 @default.
- W2018304908 creator A5053197986 @default.
- W2018304908 creator A5087408445 @default.
- W2018304908 creator A5088077097 @default.
- W2018304908 date "2015-05-01" @default.
- W2018304908 modified "2023-10-12" @default.
- W2018304908 title "Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells" @default.
- W2018304908 cites W1829371983 @default.
- W2018304908 cites W1967341601 @default.
- W2018304908 cites W1967841068 @default.
- W2018304908 cites W1982429165 @default.
- W2018304908 cites W1984340155 @default.
- W2018304908 cites W1986586739 @default.
- W2018304908 cites W1988643971 @default.
- W2018304908 cites W1989027475 @default.
- W2018304908 cites W1992788426 @default.
- W2018304908 cites W1993762503 @default.
- W2018304908 cites W2004457665 @default.
- W2018304908 cites W2007003847 @default.
- W2018304908 cites W2022140142 @default.
- W2018304908 cites W2035143183 @default.
- W2018304908 cites W2038774969 @default.
- W2018304908 cites W2044611683 @default.
- W2018304908 cites W2044830131 @default.
- W2018304908 cites W2053084007 @default.
- W2018304908 cites W2057561668 @default.
- W2018304908 cites W2060608189 @default.
- W2018304908 cites W2067102637 @default.
- W2018304908 cites W2071365780 @default.
- W2018304908 cites W2093994237 @default.
- W2018304908 cites W2094753906 @default.
- W2018304908 cites W2095115211 @default.
- W2018304908 cites W2099189400 @default.
- W2018304908 cites W2108416864 @default.
- W2018304908 cites W2117033042 @default.
- W2018304908 cites W2117637538 @default.
- W2018304908 cites W2122781654 @default.
- W2018304908 cites W2125987139 @default.
- W2018304908 cites W2152589171 @default.
- W2018304908 cites W2155870354 @default.
- W2018304908 cites W2161604785 @default.
- W2018304908 cites W2162504561 @default.
- W2018304908 cites W2175849508 @default.
- W2018304908 doi "https://doi.org/10.1016/j.stem.2015.03.002" @default.
- W2018304908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25800778" @default.
- W2018304908 hasPublicationYear "2015" @default.
- W2018304908 type Work @default.
- W2018304908 sameAs 2018304908 @default.
- W2018304908 citedByCount "158" @default.
- W2018304908 countsByYear W20183049082015 @default.
- W2018304908 countsByYear W20183049082016 @default.
- W2018304908 countsByYear W20183049082017 @default.
- W2018304908 countsByYear W20183049082018 @default.
- W2018304908 countsByYear W20183049082019 @default.
- W2018304908 countsByYear W20183049082020 @default.
- W2018304908 countsByYear W20183049082021 @default.
- W2018304908 countsByYear W20183049082022 @default.
- W2018304908 countsByYear W20183049082023 @default.
- W2018304908 crossrefType "journal-article" @default.
- W2018304908 hasAuthorship W2018304908A5000648036 @default.
- W2018304908 hasAuthorship W2018304908A5004628851 @default.
- W2018304908 hasAuthorship W2018304908A5011658917 @default.
- W2018304908 hasAuthorship W2018304908A5016484890 @default.
- W2018304908 hasAuthorship W2018304908A5021449949 @default.
- W2018304908 hasAuthorship W2018304908A5027986002 @default.
- W2018304908 hasAuthorship W2018304908A5034949085 @default.
- W2018304908 hasAuthorship W2018304908A5036805154 @default.
- W2018304908 hasAuthorship W2018304908A5042230160 @default.
- W2018304908 hasAuthorship W2018304908A5047338296 @default.
- W2018304908 hasAuthorship W2018304908A5053197986 @default.
- W2018304908 hasAuthorship W2018304908A5087408445 @default.
- W2018304908 hasAuthorship W2018304908A5088077097 @default.
- W2018304908 hasBestOaLocation W20183049081 @default.
- W2018304908 hasConcept C101762097 @default.
- W2018304908 hasConcept C104317684 @default.
- W2018304908 hasConcept C117717151 @default.
- W2018304908 hasConcept C129536746 @default.
- W2018304908 hasConcept C137338518 @default.
- W2018304908 hasConcept C145103041 @default.
- W2018304908 hasConcept C148738053 @default.
- W2018304908 hasConcept C150194340 @default.
- W2018304908 hasConcept C158448853 @default.
- W2018304908 hasConcept C167227067 @default.
- W2018304908 hasConcept C190727270 @default.
- W2018304908 hasConcept C2777116130 @default.
- W2018304908 hasConcept C2780914512 @default.
- W2018304908 hasConcept C28328180 @default.