Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018305539> ?p ?o ?g. }
- W2018305539 endingPage "624" @default.
- W2018305539 startingPage "615" @default.
- W2018305539 abstract "Because hyperammonemia is thought to contribute to the pathogenesis of hepatic encephalopathy, we examined the effects of ammonia on ATP levels, neuronal morphology, and synaptic function in rat hippocampal slices. Although ammonia did not alter ATP levels supported by 10 mM glucose, ammonia significantly depressed ATP levels in the presence of 3.3 mM glucose or 10 mM pyruvate, suggesting effects on respiratory energy metabolism. Ammonia also impaired synaptic function and neuronal integrity sustained by pyruvate. In 10 mM glucose, ammonia inhibited the induction and maintenance of long-term potentiation (LTP) in a concentration-dependent fashion. These inhibitory effects of ammonia were overcome by L-carnitine. DL-APV, an antagonist of NMDA receptors, also diminished the effects of ammonia on ATP levels and LTP induction, indicating that ammonia impairs neuronal function via altered metabolism and untimely NMDA receptor activation. These results suggest that L-carnitine and NMDA receptor antagonists have the potential to preserve neuronal function during hyperammonemia." @default.
- W2018305539 created "2016-06-24" @default.
- W2018305539 creator A5001510626 @default.
- W2018305539 creator A5021518044 @default.
- W2018305539 creator A5067324638 @default.
- W2018305539 creator A5073708443 @default.
- W2018305539 creator A5081481500 @default.
- W2018305539 date "2005-11-01" @default.
- W2018305539 modified "2023-09-25" @default.
- W2018305539 title "Ammonia-mediated LTP inhibition: Effects of NMDA receptor antagonists and l-carnitine" @default.
- W2018305539 cites W115707904 @default.
- W2018305539 cites W144988643 @default.
- W2018305539 cites W1540662041 @default.
- W2018305539 cites W1552073493 @default.
- W2018305539 cites W1623476925 @default.
- W2018305539 cites W1917708460 @default.
- W2018305539 cites W1970584427 @default.
- W2018305539 cites W1970686064 @default.
- W2018305539 cites W1973576309 @default.
- W2018305539 cites W1976759353 @default.
- W2018305539 cites W1977521326 @default.
- W2018305539 cites W1979513610 @default.
- W2018305539 cites W1980819126 @default.
- W2018305539 cites W1992045820 @default.
- W2018305539 cites W1995409393 @default.
- W2018305539 cites W2013290120 @default.
- W2018305539 cites W2013893940 @default.
- W2018305539 cites W2016388823 @default.
- W2018305539 cites W2017765795 @default.
- W2018305539 cites W2018082620 @default.
- W2018305539 cites W2023646564 @default.
- W2018305539 cites W2026036106 @default.
- W2018305539 cites W2034103378 @default.
- W2018305539 cites W2040539334 @default.
- W2018305539 cites W2041624012 @default.
- W2018305539 cites W2041867742 @default.
- W2018305539 cites W2043422509 @default.
- W2018305539 cites W2045147785 @default.
- W2018305539 cites W2046413874 @default.
- W2018305539 cites W2047717681 @default.
- W2018305539 cites W2048420531 @default.
- W2018305539 cites W2053167233 @default.
- W2018305539 cites W2059045696 @default.
- W2018305539 cites W2061656366 @default.
- W2018305539 cites W2064356193 @default.
- W2018305539 cites W2067426843 @default.
- W2018305539 cites W2071364408 @default.
- W2018305539 cites W2075472484 @default.
- W2018305539 cites W2079995698 @default.
- W2018305539 cites W2124863154 @default.
- W2018305539 cites W2139131748 @default.
- W2018305539 cites W2151208994 @default.
- W2018305539 cites W2160749102 @default.
- W2018305539 cites W2166373388 @default.
- W2018305539 cites W2316482047 @default.
- W2018305539 cites W2331270176 @default.
- W2018305539 cites W2334982407 @default.
- W2018305539 cites W4249722176 @default.
- W2018305539 cites W90952314 @default.
- W2018305539 doi "https://doi.org/10.1016/j.nbd.2005.04.013" @default.
- W2018305539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15935684" @default.
- W2018305539 hasPublicationYear "2005" @default.
- W2018305539 type Work @default.
- W2018305539 sameAs 2018305539 @default.
- W2018305539 citedByCount "25" @default.
- W2018305539 countsByYear W20183055392012 @default.
- W2018305539 countsByYear W20183055392013 @default.
- W2018305539 countsByYear W20183055392014 @default.
- W2018305539 countsByYear W20183055392016 @default.
- W2018305539 countsByYear W20183055392022 @default.
- W2018305539 crossrefType "journal-article" @default.
- W2018305539 hasAuthorship W2018305539A5001510626 @default.
- W2018305539 hasAuthorship W2018305539A5021518044 @default.
- W2018305539 hasAuthorship W2018305539A5067324638 @default.
- W2018305539 hasAuthorship W2018305539A5073708443 @default.
- W2018305539 hasAuthorship W2018305539A5081481500 @default.
- W2018305539 hasConcept C126322002 @default.
- W2018305539 hasConcept C134018914 @default.
- W2018305539 hasConcept C170493617 @default.
- W2018305539 hasConcept C185592680 @default.
- W2018305539 hasConcept C25274449 @default.
- W2018305539 hasConcept C2778435403 @default.
- W2018305539 hasConcept C2781099255 @default.
- W2018305539 hasConcept C55493867 @default.
- W2018305539 hasConcept C61174792 @default.
- W2018305539 hasConcept C67018056 @default.
- W2018305539 hasConcept C71924100 @default.
- W2018305539 hasConcept C86803240 @default.
- W2018305539 hasConceptScore W2018305539C126322002 @default.
- W2018305539 hasConceptScore W2018305539C134018914 @default.
- W2018305539 hasConceptScore W2018305539C170493617 @default.
- W2018305539 hasConceptScore W2018305539C185592680 @default.
- W2018305539 hasConceptScore W2018305539C25274449 @default.
- W2018305539 hasConceptScore W2018305539C2778435403 @default.
- W2018305539 hasConceptScore W2018305539C2781099255 @default.
- W2018305539 hasConceptScore W2018305539C55493867 @default.
- W2018305539 hasConceptScore W2018305539C61174792 @default.
- W2018305539 hasConceptScore W2018305539C67018056 @default.