Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018305866> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2018305866 endingPage "379" @default.
- W2018305866 startingPage "371" @default.
- W2018305866 abstract "The lysosomotropic amines methylamine (40 mM) and chloroquine (125 μM) prevented the killing of cultured hepatocytes by hydrogen peroxide generated in themedium by glucose oxidase. Maximum protection required several hours preincubation with either amine. Sensitivity of the hepatocytes to H2O2 was restored either by the addition of ferrous or ferric iron to the culture medium, or by incubating the cells for 4 hours in the absence of either amine prior to treatment with H2O2. Neither methylamine nor chloroquine had any effect on the cell killing by t-butyl hydroperoxide, a hepatotoxin that does not require iron. The protective effect of the lysosomotropic amines was distinguished from that of the ferric iron chelator deferoxamine in two ways: 1) deferoxamine protected hepatocytes from H2O2 toxicity but did not require a pretreatment period; and 2) in contrast to methylamine or chloroquine, deferoxamine had no effect on lysosomal pH as assessed by the fluorescent probe acridine orange. The data suggest that a lysosomal pool is the source of the ferric iron necessary for the killing of hepatocytes by H2O2." @default.
- W2018305866 created "2016-06-24" @default.
- W2018305866 creator A5002892388 @default.
- W2018305866 creator A5086539221 @default.
- W2018305866 creator A5087081177 @default.
- W2018305866 date "1985-12-01" @default.
- W2018305866 modified "2023-09-27" @default.
- W2018305866 title "Lysosomal origin of the ferric iron required for cell killing by hydrogen peroxide" @default.
- W2018305866 cites W1490154674 @default.
- W2018305866 cites W1500716310 @default.
- W2018305866 cites W1533335439 @default.
- W2018305866 cites W1570650398 @default.
- W2018305866 cites W1596679547 @default.
- W2018305866 cites W1606741128 @default.
- W2018305866 cites W1647656396 @default.
- W2018305866 cites W1903395966 @default.
- W2018305866 cites W1967353698 @default.
- W2018305866 cites W1968065552 @default.
- W2018305866 cites W1975106364 @default.
- W2018305866 cites W1987090517 @default.
- W2018305866 cites W1993476394 @default.
- W2018305866 cites W1999795482 @default.
- W2018305866 cites W2007087035 @default.
- W2018305866 cites W2114839966 @default.
- W2018305866 cites W2280422860 @default.
- W2018305866 doi "https://doi.org/10.1016/0006-291x(85)90916-7" @default.
- W2018305866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4084283" @default.
- W2018305866 hasPublicationYear "1985" @default.
- W2018305866 type Work @default.
- W2018305866 sameAs 2018305866 @default.
- W2018305866 citedByCount "60" @default.
- W2018305866 countsByYear W20183058662012 @default.
- W2018305866 countsByYear W20183058662013 @default.
- W2018305866 countsByYear W20183058662019 @default.
- W2018305866 countsByYear W20183058662020 @default.
- W2018305866 countsByYear W20183058662021 @default.
- W2018305866 countsByYear W20183058662022 @default.
- W2018305866 crossrefType "journal-article" @default.
- W2018305866 hasAuthorship W2018305866A5002892388 @default.
- W2018305866 hasAuthorship W2018305866A5086539221 @default.
- W2018305866 hasAuthorship W2018305866A5087081177 @default.
- W2018305866 hasConcept C131779359 @default.
- W2018305866 hasConcept C13965031 @default.
- W2018305866 hasConcept C178790620 @default.
- W2018305866 hasConcept C179104552 @default.
- W2018305866 hasConcept C185592680 @default.
- W2018305866 hasConcept C190283241 @default.
- W2018305866 hasConcept C2775832776 @default.
- W2018305866 hasConcept C2776672577 @default.
- W2018305866 hasConcept C2776816875 @default.
- W2018305866 hasConcept C2778969155 @default.
- W2018305866 hasConcept C2779102032 @default.
- W2018305866 hasConcept C2780534640 @default.
- W2018305866 hasConcept C533411734 @default.
- W2018305866 hasConcept C55493867 @default.
- W2018305866 hasConceptScore W2018305866C131779359 @default.
- W2018305866 hasConceptScore W2018305866C13965031 @default.
- W2018305866 hasConceptScore W2018305866C178790620 @default.
- W2018305866 hasConceptScore W2018305866C179104552 @default.
- W2018305866 hasConceptScore W2018305866C185592680 @default.
- W2018305866 hasConceptScore W2018305866C190283241 @default.
- W2018305866 hasConceptScore W2018305866C2775832776 @default.
- W2018305866 hasConceptScore W2018305866C2776672577 @default.
- W2018305866 hasConceptScore W2018305866C2776816875 @default.
- W2018305866 hasConceptScore W2018305866C2778969155 @default.
- W2018305866 hasConceptScore W2018305866C2779102032 @default.
- W2018305866 hasConceptScore W2018305866C2780534640 @default.
- W2018305866 hasConceptScore W2018305866C533411734 @default.
- W2018305866 hasConceptScore W2018305866C55493867 @default.
- W2018305866 hasIssue "2" @default.
- W2018305866 hasLocation W20183058661 @default.
- W2018305866 hasLocation W20183058662 @default.
- W2018305866 hasOpenAccess W2018305866 @default.
- W2018305866 hasPrimaryLocation W20183058661 @default.
- W2018305866 hasRelatedWork W1997264762 @default.
- W2018305866 hasRelatedWork W2018305866 @default.
- W2018305866 hasRelatedWork W2071897004 @default.
- W2018305866 hasRelatedWork W2073674161 @default.
- W2018305866 hasRelatedWork W2339834564 @default.
- W2018305866 hasRelatedWork W2353474195 @default.
- W2018305866 hasRelatedWork W3211137364 @default.
- W2018305866 hasRelatedWork W4236350793 @default.
- W2018305866 hasRelatedWork W4253116411 @default.
- W2018305866 hasRelatedWork W619605413 @default.
- W2018305866 hasVolume "133" @default.
- W2018305866 isParatext "false" @default.
- W2018305866 isRetracted "false" @default.
- W2018305866 magId "2018305866" @default.
- W2018305866 workType "article" @default.