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- W2018306089 abstract "The local lymph node assay (LLNA) is a method for the identification of skin sensitization hazard. The method is based upon measurement of proliferative responses induced in draining lymph nodes following topical exposure of mice to the test chemical. More recently the LLNA has also been used for the evaluation of relative skin sensitization potency in the context of risk assessment. Idiosyncratic drug reactions resulting from the stimulation of allergic or autoimmunogenic responses are poorly understood but represent an important clinical problem. In this article, the potential utility of the LLNA, either in a conventional modified configuration, to provide information of value in assessment the potential for systemic allergenicity is considered." @default.
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- W2018306089 date "2001-02-01" @default.
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- W2018306089 title "The local lymph node assay and potential application to the identification of drug allergens" @default.
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- W2018306089 doi "https://doi.org/10.1016/s0300-483x(00)00408-x" @default.
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