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- W2018316968 abstract "Calcium and phosphate imbalances are important mutable risk factors for cardiovascular disease in chronic kidney disease (CKD). Nearly all dialysis patients require phosphate binders. These include traditional calcium-based compounds and, more recently, the calcium-free, metal-free, non-absorbed agent, sevelamer hydrochloride. Both binder types reduce serum phosphorus, but differ with respect to calcium load and metabolism. Absorption from calcium-based agents very likely promotes positive total calcium balance in many patients. Positive calcium balance is inappropriate in adults and may promote or accelerate soft-tissue and vascular calcification even in the absence of hypercalcemia. Calcium accumulation in heart and vascular tissues contributes to rapidly progressive cardiovascular calcification - a strong predictor of cardiovascular and all-cause mortality in stage 5 CKD. More than two-thirds of stage 5 CKD patients have calcification scores above the 75th percentile for matched controls -- scores associated with extremely high risk of cardiovascular events and death." @default.
- W2018316968 created "2016-06-24" @default.
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- W2018316968 date "2005-01-01" @default.
- W2018316968 modified "2023-09-27" @default.
- W2018316968 title "Calcium Loading, Calcium Accumulation, and Associated Cardiovascular Risks in Dialysis Patients" @default.
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- W2018316968 doi "https://doi.org/10.1159/000083713" @default.
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