Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018322011> ?p ?o ?g. }
- W2018322011 endingPage "1318" @default.
- W2018322011 startingPage "1310" @default.
- W2018322011 abstract "Cyst growth in patients with autosomal dominant polycystic kidney disease is thought to be due to increased tubular cell proliferation. One model to explain this altered proliferation suggests that the polycystin proteins PC1 and PC2 localize to apical cilia and serve as an integral part of the flow-sensing pathway thus modulating the proliferative response. We measured proliferation and apoptosis in proximal tubule derived cell lines lacking PC1. These cells showed increased rates of proliferation, a decreased rate of apoptosis, compared to control heterozygous cell lines, and spontaneously formed cysts rather than tubules in an in vitro tubulogenesis assay. Addition of neutrophil gelatinase associated lipocalin (NGAL), a small secreted protein that binds diverse ligands, to the cells lacking PC1 inhibited proliferation and increased apoptosis leading to slower cyst growth in vitro. Sustained over-expression at low level of NGAL by an adenoviral delivery system suppressed cyst enlargement without improving renal function in the Pkd1 mutant mice. Our studies show that renal epithelial cells lacking PC1 have an inherent tendency to hyper-proliferate forming cysts in vitro independent of a flow stimulus. The potential benefit of attenuating cyst growth with NGAL remains to be determined." @default.
- W2018322011 created "2016-06-24" @default.
- W2018322011 creator A5009154236 @default.
- W2018322011 creator A5022619172 @default.
- W2018322011 creator A5038287284 @default.
- W2018322011 creator A5039482275 @default.
- W2018322011 creator A5048661525 @default.
- W2018322011 creator A5052367215 @default.
- W2018322011 creator A5053840136 @default.
- W2018322011 creator A5061345984 @default.
- W2018322011 creator A5083455588 @default.
- W2018322011 creator A5088426392 @default.
- W2018322011 date "2008-11-01" @default.
- W2018322011 modified "2023-10-16" @default.
- W2018322011 title "Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo" @default.
- W2018322011 cites W125106425 @default.
- W2018322011 cites W1592452759 @default.
- W2018322011 cites W1602471950 @default.
- W2018322011 cites W1783360620 @default.
- W2018322011 cites W1972537518 @default.
- W2018322011 cites W1976385326 @default.
- W2018322011 cites W1976989450 @default.
- W2018322011 cites W1991488642 @default.
- W2018322011 cites W1992960888 @default.
- W2018322011 cites W1993765367 @default.
- W2018322011 cites W2000780867 @default.
- W2018322011 cites W2006380829 @default.
- W2018322011 cites W2011505059 @default.
- W2018322011 cites W2013002334 @default.
- W2018322011 cites W2013681980 @default.
- W2018322011 cites W2020776894 @default.
- W2018322011 cites W2027480690 @default.
- W2018322011 cites W2032741126 @default.
- W2018322011 cites W2036145275 @default.
- W2018322011 cites W2036588212 @default.
- W2018322011 cites W2038682505 @default.
- W2018322011 cites W2044144053 @default.
- W2018322011 cites W2045518664 @default.
- W2018322011 cites W2045985868 @default.
- W2018322011 cites W2053023199 @default.
- W2018322011 cites W2058151768 @default.
- W2018322011 cites W2061348306 @default.
- W2018322011 cites W2061708745 @default.
- W2018322011 cites W2065603011 @default.
- W2018322011 cites W2071302452 @default.
- W2018322011 cites W2074950688 @default.
- W2018322011 cites W2075591864 @default.
- W2018322011 cites W2082227806 @default.
- W2018322011 cites W2088811685 @default.
- W2018322011 cites W2093401766 @default.
- W2018322011 cites W2095869636 @default.
- W2018322011 cites W2098587662 @default.
- W2018322011 cites W2101075545 @default.
- W2018322011 cites W2103262172 @default.
- W2018322011 cites W2103377139 @default.
- W2018322011 cites W2107211482 @default.
- W2018322011 cites W2111173668 @default.
- W2018322011 cites W2113588019 @default.
- W2018322011 cites W2119615058 @default.
- W2018322011 cites W2119747788 @default.
- W2018322011 cites W2122934045 @default.
- W2018322011 cites W2132860647 @default.
- W2018322011 cites W2134914006 @default.
- W2018322011 cites W2138061240 @default.
- W2018322011 cites W2138561620 @default.
- W2018322011 cites W2152863656 @default.
- W2018322011 cites W2160928945 @default.
- W2018322011 cites W2165466047 @default.
- W2018322011 cites W2166001167 @default.
- W2018322011 cites W2168609240 @default.
- W2018322011 cites W2169832556 @default.
- W2018322011 cites W2213951317 @default.
- W2018322011 cites W2337213344 @default.
- W2018322011 cites W2339651665 @default.
- W2018322011 cites W4240479615 @default.
- W2018322011 cites W4247088511 @default.
- W2018322011 doi "https://doi.org/10.1038/ki.2008.395" @default.
- W2018322011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3793389" @default.
- W2018322011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18974761" @default.
- W2018322011 hasPublicationYear "2008" @default.
- W2018322011 type Work @default.
- W2018322011 sameAs 2018322011 @default.
- W2018322011 citedByCount "44" @default.
- W2018322011 countsByYear W20183220112012 @default.
- W2018322011 countsByYear W20183220112013 @default.
- W2018322011 countsByYear W20183220112014 @default.
- W2018322011 countsByYear W20183220112015 @default.
- W2018322011 countsByYear W20183220112016 @default.
- W2018322011 countsByYear W20183220112017 @default.
- W2018322011 countsByYear W20183220112018 @default.
- W2018322011 countsByYear W20183220112019 @default.
- W2018322011 countsByYear W20183220112020 @default.
- W2018322011 countsByYear W20183220112021 @default.
- W2018322011 countsByYear W20183220112022 @default.
- W2018322011 countsByYear W20183220112023 @default.
- W2018322011 crossrefType "journal-article" @default.
- W2018322011 hasAuthorship W2018322011A5009154236 @default.
- W2018322011 hasAuthorship W2018322011A5022619172 @default.