Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018333615> ?p ?o ?g. }
- W2018333615 endingPage "e102327" @default.
- W2018333615 startingPage "e102327" @default.
- W2018333615 abstract "Tumor infiltrating lymphocytes (TIL) reflect the host's anti-tumor immune response, and can be a valuable predictor of prognosis. However, many properties of TIL are not fully understood. In the present study, TCR-Vβ repertoires of cancer patients were primarily analyzed by flow cytometry. Abnormally expressed TCR-Vβ subfamilies were generally found in both TIL and peripheral blood lymphocytes (PBL) of each patient. Of note, increased patient age was associated with increasingly biased TCR-Vβ repertoire in TIL but not in PBL, and the dispersion degree of the differences of TCR-Vβ subfamilies between TIL and PBL correlated positively with age (P = 0.007). Utilizing immunoscope analysis, we identified the age-related reduction in TCR-Vβ diversity, but polyclonal pattern was predominant in significantly expanded TCR-Vβ subfamilies. In addition, we found that older patients possessed a decreased ratio of CD8+CD62L+ non-effector cells in TIL compared to PBL, implying age-related increase of CD8+CD62L- effector cells in TIL. The colocalization analysis of CD8 and CD3, however, suggested the suppressed activity of these effector cells in tumor microenvironment. These findings further elucidate the properties of TIL, showing an increasing difference between TIL and PBL with age, which may provide insight for the development of effective immunotherapies for cancer patients of different ages." @default.
- W2018333615 created "2016-06-24" @default.
- W2018333615 creator A5004514476 @default.
- W2018333615 creator A5010599695 @default.
- W2018333615 creator A5019685555 @default.
- W2018333615 creator A5033859479 @default.
- W2018333615 creator A5042339155 @default.
- W2018333615 creator A5048034673 @default.
- W2018333615 creator A5058074481 @default.
- W2018333615 creator A5069811393 @default.
- W2018333615 creator A5070962397 @default.
- W2018333615 creator A5074385560 @default.
- W2018333615 creator A5076676274 @default.
- W2018333615 date "2014-07-14" @default.
- W2018333615 modified "2023-10-10" @default.
- W2018333615 title "Differences in TCR-Vβ Repertoire and Effector Phenotype between Tumor Infiltrating Lymphocytes and Peripheral Blood Lymphocytes Increase with Age" @default.
- W2018333615 cites W105517789 @default.
- W2018333615 cites W1483194800 @default.
- W2018333615 cites W1556334181 @default.
- W2018333615 cites W1623963004 @default.
- W2018333615 cites W1929611518 @default.
- W2018333615 cites W1965029629 @default.
- W2018333615 cites W1979936799 @default.
- W2018333615 cites W1995698907 @default.
- W2018333615 cites W1997508510 @default.
- W2018333615 cites W1998161202 @default.
- W2018333615 cites W2000303800 @default.
- W2018333615 cites W2008184727 @default.
- W2018333615 cites W2011800838 @default.
- W2018333615 cites W2013237079 @default.
- W2018333615 cites W2015154476 @default.
- W2018333615 cites W2019638398 @default.
- W2018333615 cites W2036374565 @default.
- W2018333615 cites W2036632555 @default.
- W2018333615 cites W2064932721 @default.
- W2018333615 cites W2078197336 @default.
- W2018333615 cites W2094767868 @default.
- W2018333615 cites W2104601608 @default.
- W2018333615 cites W2114601875 @default.
- W2018333615 cites W2115037258 @default.
- W2018333615 cites W2117535233 @default.
- W2018333615 cites W2131252883 @default.
- W2018333615 cites W2131748930 @default.
- W2018333615 cites W2133431461 @default.
- W2018333615 cites W2136573535 @default.
- W2018333615 cites W2140053672 @default.
- W2018333615 cites W2142300779 @default.
- W2018333615 cites W2142357559 @default.
- W2018333615 cites W2148262907 @default.
- W2018333615 cites W2149209349 @default.
- W2018333615 cites W2149668671 @default.
- W2018333615 cites W2150492554 @default.
- W2018333615 cites W2150662513 @default.
- W2018333615 cites W2155525214 @default.
- W2018333615 cites W2168539852 @default.
- W2018333615 cites W2168572010 @default.
- W2018333615 cites W23308010 @default.
- W2018333615 cites W4230274068 @default.
- W2018333615 doi "https://doi.org/10.1371/journal.pone.0102327" @default.
- W2018333615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096599" @default.
- W2018333615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25019226" @default.
- W2018333615 hasPublicationYear "2014" @default.
- W2018333615 type Work @default.
- W2018333615 sameAs 2018333615 @default.
- W2018333615 citedByCount "13" @default.
- W2018333615 countsByYear W20183336152015 @default.
- W2018333615 countsByYear W20183336152017 @default.
- W2018333615 countsByYear W20183336152018 @default.
- W2018333615 countsByYear W20183336152019 @default.
- W2018333615 countsByYear W20183336152021 @default.
- W2018333615 countsByYear W20183336152022 @default.
- W2018333615 crossrefType "journal-article" @default.
- W2018333615 hasAuthorship W2018333615A5004514476 @default.
- W2018333615 hasAuthorship W2018333615A5010599695 @default.
- W2018333615 hasAuthorship W2018333615A5019685555 @default.
- W2018333615 hasAuthorship W2018333615A5033859479 @default.
- W2018333615 hasAuthorship W2018333615A5042339155 @default.
- W2018333615 hasAuthorship W2018333615A5048034673 @default.
- W2018333615 hasAuthorship W2018333615A5058074481 @default.
- W2018333615 hasAuthorship W2018333615A5069811393 @default.
- W2018333615 hasAuthorship W2018333615A5070962397 @default.
- W2018333615 hasAuthorship W2018333615A5074385560 @default.
- W2018333615 hasAuthorship W2018333615A5076676274 @default.
- W2018333615 hasBestOaLocation W20183336151 @default.
- W2018333615 hasConcept C114684123 @default.
- W2018333615 hasConcept C167672396 @default.
- W2018333615 hasConcept C19317047 @default.
- W2018333615 hasConcept C203014093 @default.
- W2018333615 hasConcept C2776090121 @default.
- W2018333615 hasConcept C2776107976 @default.
- W2018333615 hasConcept C2778326572 @default.
- W2018333615 hasConcept C51785407 @default.
- W2018333615 hasConcept C86803240 @default.
- W2018333615 hasConcept C8891405 @default.
- W2018333615 hasConceptScore W2018333615C114684123 @default.
- W2018333615 hasConceptScore W2018333615C167672396 @default.
- W2018333615 hasConceptScore W2018333615C19317047 @default.
- W2018333615 hasConceptScore W2018333615C203014093 @default.