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- W2018336645 abstract "ABSTRACT The structure of skin and liver collagen fibrils after treatment with lithium chloride at a dose of 1.5 meq Li/kg of body weight was studied by electron microscopy and image processing. A method is described based on a computer-aided analysis of electron optical images of collagen fibrils, in order to measure the fibril diameter. Animals, rabbits and rats, were sacrificed 1-day, 2-, 6- and 12-months after the end of a 30 consecutive days experimental period. Fibrils in disarray interspersed with normal ones were seen, although there were areas where the normal parallel packing of fibrils was completely replaced by a random arrangement. Lithium treated collagen fibrils had a decrease in mean diameter compared to normal with a high variability in width. At later stages, clusters of fibrils were found when viewed in cross-sections, constituted approximately, 2–5% of the whole population." @default.
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- W2018336645 date "2002-01-12" @default.
- W2018336645 modified "2023-09-26" @default.
- W2018336645 title "STRUCTURAL ALTERATIONS CAUSED BY LITHIUM IN SKIN AND LIVER COLLAGEN USING AN IMAGE PROCESSING METHOD" @default.
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- W2018336645 doi "https://doi.org/10.1081/tma-120015611" @default.
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